Peptides are often treated like supplements you can stack for convenience. One for repair, one for metabolism, one for inflammation. That mindset leads people to assume they can simply mix peptides in the same syringe and inject once. The problem is peptides are not pills. They are fragile, information-carrying molecules whose behavior is governed by physics, chemistry, and biology at the same time. A peptide is not just a chain of amino acids. In solution it exists as a three-dimensional structure held together by weak forces like hydrogen bonds, electrostatic interactions, and hydrophobic effects. These forces are highly sensitive to the environment. Small changes in pH, ionic strength, or solvent conditions can change the peptide’s shape, stability, and behavior. When a peptide is manufactured, it is stabilized in a very specific formulation. That formulation controls pH, charge, ion balance, and solubility so the peptide stays folded correctly and remains biologically active. When you mix two peptides together, you destroy that controlled environment and create a new, untested chemical system. One of the first things that goes wrong is charge balance. Peptides carry electrical charge depending on pH. That charge helps keep molecules from sticking to each other. Mixing peptides can shift pH just enough to reduce repulsion between molecules. When repulsion drops, attraction wins, and peptides begin to stick together. Ionic strength matters too. Mixing solutions often increases ion concentration, which compresses the electrical “buffer” that keeps peptides apart. This allows molecules to drift close enough for hydrophobic regions to interact. Water dislikes exposed hydrophobic surfaces, so peptides clump together to lower free energy. This is basic solution physics. Once aggregation starts, it accelerates. A few misfolded molecules form a nucleus, which seeds further aggregation. Early clumps may be invisible, but they still matter. They reduce the amount of active peptide, alter absorption, and change signaling behavior.

This question keeps me worried all the time. Alex Kikel mentioned it multiple times. That through receptors crass-talk it can do it. What's your personal opinion on it? Is it possible technically ? Do you know someone who suffered from gyno caused by SLU ?

@Anthony Castore Hi, I’m looking for some guidance on a limited supplement protocol for my 84yo mother. A bit of her background- as stated, she’s 84 years young, has no major health issues; has sporadic cases of skin cancers on her face, had a kidney stone a few years ago, and has had a hip replacement, she doesn’t exercise (though up and about majority of the day everyday), does NOT pay attention to her lifestyle or nutrition (HEAVY carbohydrate intake), does not take any medications. It amazes me how “healthy” or at least symptom free she is when she does EVERYTHING wrong in terms of health and performance. She goes against just about everything I know and have learned and preach as a Health and Performance Consultant, which is wild to me haha shows how complex health truly is, and how much we still don’t understand Here’s what I’m thinking about having her take daily- omega 3s and spirulina+chlorella. To me, these will cover just about everything from a structural, pliability, immune, and deep nutritional aspect. I’m playing with either CLO or Resolvin from BodyBio (leaning towards Resolvin). Thoughts? The thing with the spirulina+chlorella is the amount of tabs needed daily (10+). She hates taking pills/capsules, so I also like the idea of using Human Potential (freeze dried bison organs). This way she could open the capsules and sprinkle the nutrients on her food or mix in her tea or whatever. I also really like, and would love for her to take would be C60 and PC from BodyBio. Giving her cells and membranes some direct love will obviously be hugely beneficial, but if I can only give her 2 things to focus on for now, I think omega 3s and a broad spectrum of nutrients, enzymes, peptides, and bioactives will cover more needs. Even sulforaphane for the Nrf, BDNF, etc… What do you think here? What would you change or add/swap? Obviously lifestyle and nutrition come first, but there is no chance I’m getting her to change those behaviors and habits at this point, so I want give her a few easy things to take daily to ensure her body/biology are being provided what they need so she can have a better health span at this point in her life and going forward. Thank you for any advice!

@Anthony Castore As far as the nutrition on certain days https://youtu.be/roB4KfR-_hg?si=ry06iHvv5ta2Y2q3

I'm convinced about the benefits of BFR and CO2 therapies and I own both devices. However, for someone who isn't an athlete and just wants to have physical and mental energy throughout the day, is EWOT the best addition or a waste of money? I searched for EWOT here and it doesn't seem like people are talking about it.