This summary was created in 5 minutes with Claude Sonnet 4.6 Images and infographics are included. + BONUS, summary of this new paper from February 23, 2026 from the same author https://www.cell.com/current-biology/abstract/S0960-9822(26)00064-3 Enjoy! And let me know what you think about it.

How are we dosing glutathione?

@Anthony Castore , I am at the last stage of my fat loss and I have another 10-15 pounds to lose to come down to 12% body fat. I lost 38 pounds in the last 9 months on Reta. Now, I want to accelerate fat loss and lose the last 10-15 pounds. I workout 4 days a week and zone 2 cardio 3-4 days a week. Diet is also on point. I read your fat loss decoded series and would like to know is it the right time to include ss-31 along with mots-c and slu-pp-332. If yes, what should be the dosage of ss-31?

Hello All! Anyone familiar with Testagen? (Not for me, for my husband) I’m the one who does all the learning/reading and goes from there. Lol He is 49, pretty healthy, no major issues, muscular, other than lots of sports injuries that have caught up with him. We eat healthy, workout, lift, play sports still, his man parts still work great (lol) he’s been taking BPC157, GHK-CU for 5 weeks, 2 weeks of TB500, 5amino & NAD (which I will not be using anymore 🫣) with zero improvement in pain, inflammation, & energy. I’ve have a lot of improvements with them and the ones I take…. , after listening to Anthonys calls and comments …. I am ordering SS31 & TA1 to heal his Mito first……before I continue to throw peptides at him….. then will add KPV. However: He hasn’t done a blood test but have friends his age on TRT and love it. Thinks he needs to do that for energy and drive to workout it’s gotten way worse in the last year. but I came: came across Testagen so did some digging and it aides ur body into producing testosterone. It’s a 4-amino acid peptide bioregulator, thyroid-stimulating hormone. Searched on here an no mentions of it….. so thought I’d post the question :) (We have kids, he has a vasectomy, everything works as it should) Is Testagen something that would help raise it without going thru all the trt clinics? His regular doc won’t even consider testing his testosterone levels or giving it. So besides a trt clinic I don’t have many options in WI for docs willing to even discuss options.

Low energy is one of the most common complaints in medicine, coaching, and everyday life, yet it is one of the least precisely understood. People describe it as fatigue, burnout, brain fog, weakness, lack of motivation, or feeling “offline.” Athletes feel it when they cannot train. Patients feel it when they cannot work. High performers feel it when discipline no longer works. The problem is that “low energy” is not a diagnosis. It is a surface description of a system-level failure, and two people can experience nearly identical symptoms while the underlying biology is completely different. Treating them the same way helps one person and harms the other. To understand low energy correctly, you have to stop asking how to boost energy and start asking why energy is being limited in the first place. At the deepest level, there are two dominant failure modes. In one, the body cannot produce enough energy. In the other, the body is deliberately suppressing energy production. The first is mitochondrial damage, a capacity problem. The second is inflammatory inhibition, a regulatory decision. One is a broken engine. The other is a functioning engine with the brakes applied. Subjectively they feel similar. Biologically they are opposites. Everything that follows depends on recognizing which one you are dealing with. A simple model helps. Imagine the body as a car. The mitochondria are the engine. They take fuel and oxygen and convert them into usable energy in the form of ATP. Inflammation acts like the central control computer, deciding how much power the engine is allowed to produce. If the engine is damaged, pressing the accelerator does little. If the computer is limiting output, the engine could perform, but is being intentionally restrained. In both cases the car goes slow. Only one responds to pushing harder. Mitochondria exist inside nearly every cell and are responsible for producing ATP, the molecule that powers muscle contraction, nerve signaling, hormone synthesis, immune regulation, tissue repair, and cognition. Without adequate ATP, nothing in the body functions well. Energy production depends on intact mitochondrial membranes, functioning enzymes, proper redox balance, sufficient oxygen delivery, and a steady supply of micronutrients. When any part of this system is damaged, the maximum amount of energy the body can generate drops. This is not a motivational issue. It is a hard ceiling.