Activity
Mon
Wed
Fri
Sun
Aug
Sep
Oct
Nov
Dec
Jan
Feb
Mar
Apr
May
Jun
Jul
What is this?
Less
More

Memberships

33 contributions to Castore: Built to Adapt
Elderly man
Hello Hello, any tips to help and old 70 years old man increase his appetite. He lost a lot of weight and muscles du to diarhea , being pre diabetic and not having appetite. Now he suffer from constipation or incomplete elimination and lack of appetite which affect his total energy
0 likes • 11d
1) Comprehensive microbiome test - GI MAP or Biomesight at least 2) Breath test for H. Pylori 3) Breath test for SIBO 4) Fasted glucose + Fasted insulin blood test Correct diagnosis first - interventions after
🎉 We're officially open — and your first gift is on the house
Hey everyone — the community is live, and I'm kicking it off with something free for everyone: two expert webinars now, a third on Monday. Here's how to watch, what's inside, and how to join us. ▶️ Watch the free webinars — free for everyone through Friday, June 19 Leonard Pastrana and Dr. Dean St Mart are open to all right now. I've extended the free window through Friday, June 19 so anyone who couldn't catch them live still gets the full sessions — no rush, no FOMO. After Friday they move into the members' area. 1. Click Classroom up top. 2. Open "Expert Series: Leonard Pastrana" or "Dr Dean St Mart." 3. Click the lesson title on the left to open the post. 4. Click the share.descript.com link near the top — the video plays with the full transcript beside it. 5. Not loading? Tap the link, then Open in browser (Chrome/Safari). Fixed. 👍 🗓️ Monday: my brand-new Coach's Protocol webinar — also free for everyone through Friday, June 19, then it becomes a monthly members' feature with the full archive. Don't miss the free window. ⏳ Here's the thing: after Friday these live in the members' area — and there's a new expert interview + Coach's Protocol every single month. If you want to keep watching, now's the moment to join. 🔬 Start here: Biochemical Fluency (the one that flew under the radar — don't sleep on it) Ever felt lost when people throw around AMPK, mTOR, Nrf2, redox? This is the course that fixes that for good. The idea: you're not bad at science — you were just never given the map. This is the map. An 8-week program that teaches you to think in mechanisms, not memorize facts: • Wk 1–2: the cell's operating system + decoding any term from its name • Wk 3–4: energy currencies, redox, and mitochondria up close • Wk 5: the master switches — AMPK ⇄ mTOR, Nrf2 ⇄ NF-kB, HIF-1α + PGC-1α • Wk 6–7: inflammation, repair, and reading any intervention or claim like a pro • Wk 8: capstone — the whole map on one page Every week ends with a Fluency Lab, worksheets, and Quizlet flashcards so it sticks. By the end you'll follow — and join — conversations that used to go over your head.
1 like • 19d
@Anthony Castore Hi Anthony. I'm surprised to see such comment from you. Iwas watching your Coaches Protocol webinar and really enjoying it, and then this Diva started appearing on the screen with her audio turned on while talking to someone in her room. She appeared once, then twice. On the 5th time I left this comment. She apparently was not listening to you, because if she did she would see her voice and image appearing on the screen and interrupting your presentation. So I consider her to be disrespectful not only to me but to you as well. I think this is unacceptable and should be called out. Community members should respect each other.
1 like • 19d
@Anthony Castore anyways, I got what you say. I'll keep such comments to myself further on 🤷🏻‍♂️
Your Testosterone Is Not the Problem: 8 Cofactors That Decide Whether TRT Actually Works
Most guys starting TRT obsess over the hormone and ignore the system carrying it. They google “best TRT stack,” buy ten bottles, and wonder why they still feel flat at week six. Here is what almost no one tells you: testosterone is not a thing you add. It is a signal you turn up. And when you turn up the signal, every wire, breaker, and exhaust pipe in the body has to handle the new load. Get that part wrong and you will blame the testosterone for problems your support system was never built to handle. Get it right and the same dose works two or three times harder. This is the part the forums skip. The usual framing is “what stacks with T?” The better frame is: what does my system now need to handle restored androgen signaling? Testosterone is not just “the man hormone.” It is a downstream signal that pulls on mitochondrial output, redox balance, membrane biology, hepatic clearance, and even the gut. When you restore that signal, you are not just adding a hormone. You are upgrading the demand on every system that was running on a quieter version of you. I think about this through three lenses: cellular metabolism, immune metabolism, and the microbiome. Anything you put in your mouth should earn its keep through at least one. THE FRAME TRT is a metabolic upgrade, not just a number on a lab sheet. Imagine your body was a workshop running at half power. TRT turns the lights back on. The saws cut faster, the welders work harder, the coffee pot runs all day. Great. But the wiring (cell membranes), the breaker box (mitochondria), the trash service (liver and bile), and the fire department (antioxidant defenses) all have to scale up too. When any of those lag, you get the symptoms people blame on testosterone: water retention, mood swings, brain fog, “high E2 feel,” fatigue. Usually it is not the T. It is the support system. WHAT YOU ARE ALREADY DOING RIGHT, WITH SMALL REFINEMENTS Vitamin D. Good. D is technically a steroid hormone and signals through the same nuclear receptor family as testosterone. Pair it with K2 (MK-7, 100 to 200 mcg) if you are not already. D pulls calcium into the blood. K2 directs it into bone and away from arteries. On TRT, where lipids and hematocrit can shift, you want calcium in your skeleton, not your aorta.
2 likes • May 8
"methyl cycle, which is how your liver clears estrogens through COMT (Phase II detox)" This was something new that I learned from this article. I mean, I've heard that there's a COMT but had no idea what it does, I thought it's somehow related to dopamine.
Terz cycle going great...what about that sweet bottle of SLU that I have?
Ahoy everyone! Just thinking through something. I'm in month two of my first cycle of Terzepitide. Nice even body fat reduction, lower dosing as I am a hyper responder, minimum sides. Will be riding this out for a few more months. I wanted to get some opinions...maybe @Anthony Castore can chime in. I have one bottle of SLU in house. 30 capsules of 100mcg per capsule. How might I use this bottle of SLU to enhance the effects of this Terz cycle? I am wont to stay away from stacking because I don't want to over signal. What are the options here? Wait till I am done with Terz and just run that bottle of SLU? Wait till I am done with Terz and get more SLU and run a greater amount over a longer period of time? Throw the SLU in during my taper-off from Terz...so, a little bit of stacking? Or... Risk wasting the money I spent on the SLU and just throw it in to the middle of the Terz cycle and see what happens...for the sake of science? : ) Thoughts?
1 like • Apr 26
It's Tirz, not Terz. SLU - not worth it in my opinion. Especially at this tiny 100mcg doses. Certainly you'll not oversignal. You'll undersignal and feel nothing. I've experimented with 2mg SLU daily - no acute and long-term effects noticed.
PART 3 The Decision Engine: How to Choose What Comes Next
Once the foundation is stable, the question changes. You are no longer asking what should I take every day. You are asking what exactly needs to change in the system right now. Take a simple example. Two people both feel fatigued. One uses caffeine and feels worse, more wired but less productive. The other uses caffeine and feels better, more focused and energized. Same symptom, completely different response. The difference is not the tool. It is the state of the system it was introduced into. This is where most people fall back into old habits. They feel better, they add more. They hear about something new, they layer it in. The system improves slightly, then becomes inconsistent again. Not because the tools are wrong, but because the decision process is missing. Most people are not lacking options. They are lacking precision. More inputs without a clear target create more noise, not more progress. If Part 2 was about stabilizing the terrain, Part 3 is about building a repeatable way to make decisions inside that terrain. Not guessing. Not copying protocols. Not chasing trends. Identifying what the system is doing, what it needs to do differently, and selecting the smallest input that can create that shift. This decision engine sits on top of a stable foundation and downstream of environment and circadian inputs. Without that context, even the right decision can produce the wrong outcome. This is the point where most protocols quietly lose precision. The decision process can be simplified into three steps. Identify the bottleneck, define the direction of change, and match the mechanism to the goal. The first step is identifying the bottleneck. Not the symptom, but the constraint underneath it. Two people can both feel fatigued and have completely different bottlenecks. One may have a system that is over-reduced, where electron supply exceeds the system’s ability to process it, creating a backlog of pressure through the electron transport chain and inefficient energy production. Another may have a system that is underpowered, where there is insufficient substrate or signaling to drive adequate ATP production.
3 likes • Apr 7
@Curtis Smith You may be a perfect example of trying to optimize broken system too much.I already see obvious things - 1) low ferritin but don't actively supplementing with iron. Your liver is not enough. Do full genome testing such as https://dantelabs.com/whole-genome-sequencing/ https://dnacomplete.com/ also I highly suggest reading this article https://www.vitalmetrics.org/blog/iron-paradox-trt and other blog posts here https://www.vitalmetrics.org/blog/ 2) what's the point of carnivore diet? You are likely starving your microbiome and have big problems in that department. Solution is prebiotic fiber supplementation at least, consider changing the diet to a healthy diet. Do microbiome testing https://shop.biomesight.com/collections/frontpage/products/gut-microbiome-test-snapshot?variant=32130724364420 or GI Map (more expensive) 3) you are heavily on the hormone therapy, not only TRT but also Thyroid - this is already adding a lot of variables that can mess your system. What I personally think is that a lot of people start TRT but then have more problems with libido and health than before. There's a guy who I would listen to if I was on TRT https://www.youtube.com/@CortexLabsChannel I have no idea of what symptoms are you referring to, but without all these extensive testing you will not find a solution, given all your interventions. Which are now questionable, given that you are actually getting worse then before.
1 like • Apr 14
@Curtis Smith I didn't know you are 72, you look younger! Thanks for the context.
1-10 of 33
Anton Sh
4
85points to level up
@anton-shakh-8960
😎

Active 3d ago
Joined Nov 5, 2025
Powered by