@Anthony Castore Hi, I’m looking for some guidance on a limited supplement protocol for my 84yo mother. A bit of her background- as stated, she’s 84 years young, has no major health issues; has sporadic cases of skin cancers on her face, had a kidney stone a few years ago, and has had a hip replacement, she doesn’t exercise (though up and about majority of the day everyday), does NOT pay attention to her lifestyle or nutrition (HEAVY carbohydrate intake), does not take any medications. It amazes me how “healthy” or at least symptom free she is when she does EVERYTHING wrong in terms of health and performance. She goes against just about everything I know and have learned and preach as a Health and Performance Consultant, which is wild to me haha shows how complex health truly is, and how much we still don’t understand Here’s what I’m thinking about having her take daily- omega 3s and spirulina+chlorella. To me, these will cover just about everything from a structural, pliability, immune, and deep nutritional aspect. I’m playing with either CLO or Resolvin from BodyBio (leaning towards Resolvin). Thoughts? The thing with the spirulina+chlorella is the amount of tabs needed daily (10+). She hates taking pills/capsules, so I also like the idea of using Human Potential (freeze dried bison organs). This way she could open the capsules and sprinkle the nutrients on her food or mix in her tea or whatever. I also really like, and would love for her to take would be C60 and PC from BodyBio. Giving her cells and membranes some direct love will obviously be hugely beneficial, but if I can only give her 2 things to focus on for now, I think omega 3s and a broad spectrum of nutrients, enzymes, peptides, and bioactives will cover more needs. Even sulforaphane for the Nrf, BDNF, etc… What do you think here? What would you change or add/swap? Obviously lifestyle and nutrition come first, but there is no chance I’m getting her to change those behaviors and habits at this point, so I want give her a few easy things to take daily to ensure her body/biology are being provided what they need so she can have a better health span at this point in her life and going forward. Thank you for any advice!

Hi, I know I posted this question in a response to another article, but it didn’t get a reply, so I’ll post it here and hopefully it’ll get a reply :) What can we do if we, or someone we know/work with, has a fish/shellfish allergy? The benefits of these food sources are unmatched and should be staples in our diet, but what if someone can’t eat them? Where should we start? Are we looking at alternatives? What would those alternatives even be? I know lamb is a good option for omega 3 content, but is it comparable? Spirulina + Chlorella are good here as well, but they’re non meat based, so it changes the equation. Are we looking at immune regulation? Exposure techniques? Gut focus? I know allergies stem from a dysfunction and mis/lack of communication between the immune systems (innate and adaptive), as well as from the skin-gut-immune-brain axis, so is getting circadian biology in rhythm over time and exposure the way to victory? Are there other ways to get these highly important molecules and nutrients into play with these kinds of individuals without consequences? I know Leviathan Nutrition has an ‘advanced omega’ product that uses lysine bound free fatty acid omega 3s along with sesamol to help package and deliver the omegas to appropriate tissues. Is this a viable option even for individuals with allergies? I’d believe so because the omegas are removed from the fish and in a different form, but could that also take away or not be such a great thing since it’s further from how nature intended? Or is there something in omega 3s inherently that would still cause a reaction? @Anthony Castore

Most people think of seafood as “protein plus omega-3s.” That framing is incomplete. What actually makes marine foods unique is not just the fats they contain, but how those fats are organized inside membranes. This organization happens through phospholipids, and phospholipids determine how cells breathe, signal, contract, recover, and adapt. If you want to understand muscle performance, brain health, recovery, inflammation, or aging, you have to understand membrane biology first. This article will walk through what phospholipids are, why membranes matter more than isolated nutrients, and how mussels, mackerel, sardines, and anchovies differ at a molecular level. We’ll move from beginner-friendly analogies to mitochondrial signaling and redox chemistry, and end with clear takeaways for clinicians and strength coaches. Start with a simple picture. Every cell in your body is wrapped in a membrane. Every mitochondrion inside that cell is also wrapped in membranes. These membranes are not passive walls. They are active, dynamic surfaces where energy transfer, signaling, and adaptation happen. The material those membranes are made of determines whether signals flow cleanly or break down into noise. Phospholipids are the structural units of membranes. Each phospholipid has a “head” that interacts with water and “tails” that interact with fat. When billions of them line up, they form a flexible, semi-fluid surface that proteins, receptors, enzymes, and ion channels embed into. If the phospholipid composition is poor, those proteins still exist, but they don’t work properly.A useful analogy is a racetrack. The engines (mitochondria) and drivers (enzymes) matter, but if the track surface is cracked or unstable, performance suffers no matter how strong the engine is. Phospholipids are the track surface. There are several major classes of phospholipids relevant to human physiology. Phosphatidylcholine (PC) provides membrane structure and transport. Phosphatidylethanolamine (PE) contributes to curvature and mitochondrial dynamics. Phosphatidylserine (PS) is critical for signaling, especially in neurons and muscle activation. Then there are plasmalogens, a special subclass with a unique chemical bond that gives them antioxidant and redox-buffering properties.

One of the coolest things I’ve learned in this space came from Dr. Seeds. He is an extraordinary thinker and an exceptionally generous teacher, and this insight fundamentally changed how I understand inflammation. What makes it so powerful is not just the biochemistry, but the way it reframes old, familiar tools in an entirely new light. This concept connects aspirin, omega-3s, and resolution biology in a way that is both elegant and practical, and it’s a perfect example of Dr. Seeds’ ability to share deep, clinically meaningful knowledge with clarity and humility. At first glance, aspirin and fish oil look like simple, even old-fashioned tools. Aspirin has been around for more than a century, and fish consumption has been part of human diets far longer than supplements or pharmaceuticals. Yet when you zoom in to the molecular level, the interaction between aspirin and omega-3 fats reveals one of the clearest examples of how small biochemical changes can redirect entire inflammatory programs in the body. This is not about suppressing inflammation, but about teaching the body how to finish it. To understand why this matters, it helps to reframe inflammation itself. Inflammation is not a mistake or a flaw. It is a necessary biological response to injury, infection, or stress. The problem is not that inflammation turns on, but that in many modern contexts it does not properly turn off. The shutdown phase of inflammation is not passive. It is an active, enzyme-driven process governed by a class of signaling molecules called pro-resolving mediators, often abbreviated PRMs or SPMs. These molecules are the biochemical equivalent of a cleanup crew. They signal immune cells to stop recruiting reinforcements, clear debris, and restore tissue to normal function. The raw materials for these mediators come from fats stored in cell membranes. Specifically, long-chain fatty acids with 20 to 22 carbons. The most familiar of these are arachidonic acid, an omega-6 fat, and EPA and DHA, the omega-3 fats found in fish. These fats are not just calories. They are precursors to powerful signaling molecules. What determines whether they become inflammatory signals or resolving signals is the enzyme environment they encounter.

Curious what the community might recommend in this situation. my 78 year old dad is finding himself not being able to think of certain words during conversations. He’s aware of it. His thought patterns are otherwise normal but i speak with him daily and see these patterns of struggle to remember certain things or think of the word he means to say. I know it’s a combination of atrophy of the brain and micro vascular atherosclerosis in the brain causing this. Peptides are not an option for him. He will not inject. curious if anyone found anything particularly useful for an aging parent with the same type of memory lapses? Thanks!!!