Curious what the community might recommend in this situation. my 78 year old dad is finding himself not being able to think of certain words during conversations. He’s aware of it. His thought patterns are otherwise normal but i speak with him daily and see these patterns of struggle to remember certain things or think of the word he means to say. I know it’s a combination of atrophy of the brain and micro vascular atherosclerosis in the brain causing this. Peptides are not an option for him. He will not inject. curious if anyone found anything particularly useful for an aging parent with the same type of memory lapses? Thanks!!!

Why are we (the collective “we”) not talking about Cardarine more? It’s effective, and it’s cheap as hell, win win IMO. I get that these peptides, small molecules and whatnot are the hot topic nowadays, rightfully so, but why isn’t Cardarine in that discussion? I’ve personally seen good results with using carnitine and Cardarine together, and now I’m looking at bringing in SLU and the other mitochondrial players. How would I use Cardarine along with carnitine, SLU, mots c, etc.? I’ve used carnitine and Cardarine pre training with good success, but like all of us here, I want to keep improving Like I mentioned, I’ve used carnitine and cardarine pre training (substrate session) thinking that I’ll spare muscle glycogen, therefore improving performance, by enhancing fat usage and stimulating PGC-1 in a training environment would help make sure those new mitochondria are exposed to that environment. But if I’m looking to build my glycolytic system, maybe that’s not the best approach, and keep those players on more metabolic days? @Anthony Castore

Been doing a fair amount of research on where to start with balancing/improving mitochondria health. I’ve got it narrowed down to starting ARA-290 or 1-MNA or urethane A. Should I start with one of these or can they be run concurrently? Any advice would be appreciated!

I’m testing out something new and wanted to bring you all along for the ride. I’ve started a daily learning experiment where I study new material each morning and then teach it back here to lock it in and spark better conversations inside the community. The goal is twofold: it helps me deepen my own understanding and gives all of us a chance to explore new ideas together. Some of what I’ll be diving into might sound a little weird at first it’s on the edge of where cellular medicine, physics, and performance meet but that’s exactly why I want to share it here. This is me getting my reps in, learning how to explain complex ideas simply so I can keep improving the way I teach and support everyone who trusts me with their health. Skool is officially in session and this is Day One. Coherence is one of those concepts that sounds abstract until you feel it. Every living system, from a single cell to a full human being, depends on rhythm and timing. When that rhythm is in sync, energy flows efficiently, signals are clear, and the system performs at its best. In biology, this rhythm is called coherence. Inside your cells, coherence is the difference between energy being stored as ATP or lost as heat and inflammation. Each mitochondrion operates like a small power plant. Its inner membrane holds a separation of charge about minus one hundred eighty millivolts that acts like the height difference of water behind a dam. This energy difference is the reason mitochondria can turn food and oxygen into usable fuel. Protons are pumped to one side of the membrane, building pressure, and when they flow back through the turbine-like ATP synthase, energy is released in a controlled, efficient way. If the membrane potential weakens, it’s like the dam lowering; water spills over without spinning the turbines, and you feel it as fatigue or slower recovery. In training terms, imagine the smooth rhythm of a strong set of squats. At the start, your body and breath are synchronized. Energy moves cleanly, the movement feels effortless, and power output is high. As fatigue builds, you lose that rhythm. The burn you feel in your muscles is the result of protons accumulating faster than they can be cleared. The gradient across your mitochondrial membranes collapses, energy flow becomes noisy, and contraction efficiency drops. That sensation is coherence breaking down in real time.

Has anyone had any experience with daily, or pre training lower (1-2mg) doses of MOTS-c? If we’re looking at genomic (chronic) and non genomic (acute) actions, and MOTS-c has some pretty cool acute effects, wouldn’t we want to take advantage of that stimulation frequency?