How does everyone feel after coming off MotsC (3-5mg 3-5 times a week), NaD+ (25-100mg 3-5 times a week) at these doses? I see these doses being shared regularly so I’m basing my thoughts off of this. This is only for myself and I always react different with medication, etc. The highest I went to on MotsC was 1mg five days a week and I had trouble sleeping because I had so much energy so I backed it down to 500mcg 3-5 days and it was my sweet spot. Nad+ I stay between 10-20 mg 3-5 times a week. I just don’t need anything more and it’s too much for me personally. I may even be missing out on other benefits of these because I can’t reach the “recommended” doses. Last year I went through the process and doses I just shared and then did SS-31. I regretted coming off both MotsC and NaD+ because I did see and feel a noticeable decline in energy through the SS-31 only. After completed though and when I eventually went back to MotsC it was absolutely amplified and it made me a believer in the work that was being done through SS-31. The previous 500mcg that was right for me was now like the original 1mg dose so I decreased to 250mcg for a while and then gradually increased back to 500mcg. I think this was two-fold; one from the SS-31 doing its job and two from allowing my body to reset and going back fresh to the MotsC. My question is when you’re at these higher and recommended doses how do you feel when you come off? Do your energy levels tank and you feel a noticeable difference? Do you gradually decrease the last couple weeks to not feel the drastic change? Do you move to another mitochondrial peptide to maintain and never experienced pulling off something completely Experiences with SS-31? I’m asking for the sake of knowledge and understanding a bit more and I’m looking for personal experiences to pull from. Thanks group!

A few months ago a coach messaged me about an athlete whose situation could have described almost anyone training at a high level. Training was going well, sleep looked decent, and the nutrition was cleaner than most people manage in a lifetime. But recovery felt off. Not broken delayed. The athlete could still produce force and grind through hard sessions. He just couldn’t get his nervous system back online afterward. Morning readiness drifted down week over week. Lactate sat elevated longer than it should have. The way he put it was more precise than most: “I can make energy. I just can’t seem to get it back.” That line stuck with me, because it lands on a question cellular medicine keeps running into. What if the limiting factor isn’t the ability to produce energy, but the ability to restore balance once energy has been spent? Most athletes treat fatigue as an energy deficit, and sometimes that’s exactly what it is. But often it’s a distribution problem. And in some cases what you’re really looking at is a redox bottleneck the cell sits in an over-reduced state, metabolic flexibility slows, substrate turnover lags, and recovery drags behind. The vocabulary is heavy; the experience is simple. You train hard, you should recover, and you don’t. That gap is what led me to put together a small pilot framework something for coaches, clinicians, and curious athletes who’d rather think like investigators than collect supplements. The hypothesis is plain. If an over-reduced phenotype is slowing lactate clearance and blunting vagal recovery, then improving NAD+ availability and mitochondrial efficiency should move two things you can actually measure: how fast lactate clears after a standardized sprint, and how well the nervous system recovers overnight, tracked through morning RMSSD. Read together, those two numbers tell a surprisingly complete story. Picture a city emptying out after a big game. Tens of thousands of people leave at once, traffic stacks up, the roads choke. The interesting question was never whether the city can move people obviously it can. It’s how fast normal flow returns. Recovery works the same way. Training generates metabolic traffic: lactate climbs, sympathetic drive climbs, fuel demand climbs. What matters is how quickly order comes back once the session is over.

A colleague of mine suffers from severe migraines. They always start just two days before her period. Doctors say it's hormonal. She's not sure and doesn't want to take hormones because she's very young. They also recommended Botox injections from her forehead to her neck, but she doesn't want that either. What can help her reduce or eliminate her migraines?

Hi Anthony , are you familiar with Bio longevity labs FLGR242 , it’s a modified follistatin? If yes can you share your opinion on it? Thank you