@Anthony Castore In researching available exogenous options, I have come across one called Original Ketones by americanketone.com. It was mentioned by Dr. Ben Bikman on a podcast. Each bottle contains 80 grams of bioidentical BHB just like Kenetik Pro, except it costs quite a bit less per bottle. Do you have any thoughts pn this product by americanketone.com?

Hi Anthony, I recently saw this rodent study done by Ben Bikman's lab on BHB and 1,3 BD. https://www.mdpi.com/2072-6643/18/4/675 This study found: "1,3 BD induces significant hepatic stress characterized by ATP depletion, oxidative stress, and lipid accumulation. These results align with and extend recent findings by Ari and D’Agostino demonstrating formulation-dependent hepatic outcomes of chronic ketone supplementation, where ketone salts preserved liver health while BD-based ketone esters and precursors drove inflammation and steatosis" What are your thoughts on their findings? Does their study design bias the outcome? Are there similar studies that show that 1,3 BD is neutral in its effects? Does KineticPro or KE4 use ketones that are different than what was studied here? (It looks the same to my naive and uninformed eyes, so that's why I'm asking.)

Human performance is governed by a simple truth: you do not adapt from the training you do you adapt from the training you recover from. Progress in the gym, in sport, and in health depends entirely on your body’s ability to restore, rebuild, and regenerate after stress. The problem is that most people push far harder than their physiology can recover from, and they only realize they’ve gone too far when fatigue, irritability, pain, or stalled results finally appear. What if you could detect the earliest microscopic signs of under-recovery long before you felt them? What if you could know, with biological precision, when to train hard and when to deload? Two tools HRV (heart rate variability) and DFA-α1 (detrended fluctuation analysis alpha-1) give us exactly that ability. Together they act as a conversation between your autonomic nervous system, your mitochondria, and your training program. Understanding them gives you one of the most powerful levers in all of performance, because they measure something we almost never get real-time access to: how stressed your cells are and how your nervous system is coping with that stress. To understand how HRV and DFA-α1 work, imagine your body as a city powered by millions of tiny power plants—your mitochondria. Training is a controlled stressor that increases demand on those power plants. If the city’s workers repair and restore everything overnight, the city grows stronger. If the workers fall behind, repairs pile up. Before you notice a major problem, there are tiny warning signs: flickering lights, unstable power lines, and irregularities in energy output. HRV and DFA-α1 sense those irregularities before they become big enough for you to feel. Heart rate variability measures the tiny differences in time between each heartbeat. Contrary to what people expect, more variability is usually a good thing, because it reflects strong vagal tone and flexible autonomic control. High HRV means your nervous system can shift gears easily between stress and recovery. Low HRV means you’re stuck in a narrow pattern often sympathetic dominance signaling strain on cellular metabolism. The morning HRV reading is the “overnight repair report” of your internal city.

An Orally Active ERR Agonist, SLU-PP-915, Enhances Aerobic Exercise Capacity (1 December 2025) The authors stress that 332 is NOT orally bioavailable. "We previously developed a ERR pan-agonist, SLU-PP-332 (332), which improve aerobic performance in mice but lacks oral bioavailability. Here, we characterize SLU-PP-915 (915), a chemically distinct ERR pan-agonist that is orally bioavailable and exhibits potent in vivo exercise mimetic activity." Who can help to get the full paper and interpret the findings? Specifically , is there any new data on how much exactly SLU-PP-332 orally bioavailable (%) ?

Hey everyone, I know @Anthony Castore is a fan of the Alpha Stim device. This past weekend I got the try the Nuropod (ear-electrode vagus nerve stimulator) for sleep/HRV/nervous system regulation. I know many of you use Alpha-Stim (cranial electrotherapy), from my understand the technology used by Nuropod has a more different influence on vagal tone because it uses transcutaneous auricular vagus nerve stimulation (taVNS) vs the Cranial Electrotherapy Stimulation (CES) used by Alpha Stim. Does anyone here use Nuropod? And for those who have tried both, how would you compare?