Activity
Mon
Wed
Fri
Sun
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
Jan
What is this?
Less
More

Memberships

Real Primal Human

80 members • Free

DDT Method

122 members • $10/m

Castore: Built to Adapt

688 members • Free

Project Biohacked

9.4k members • Free

Peptide Researchers

6.2k members • Free

9 contributions to Castore: Built to Adapt
ATX-304
Whose used this? I have some, running 200mg a day, deffo sweat a bit more during cardio, if I combine it with SLU I get a noticeable increase in body temp. Not sure on dosing as see people saying once per day, multiple times etc. Anyone got experiences and share what they have found?
0 likes • Dec '25
Anyone know what the half-life is or how are you guys dosing it? Once a day, preworkout or multiple times a day? Just got mine in the other day have only done 100 mg once a day for the last two days.
1 like • Dec '25
@Keith Greiner that’s just me getting my body used to the compound before I raise the dose. I don’t believe in getting in a cold truck and immediately going straight to 60 mph. Rather was trying to figure out if you guys are using it preworkout all in one dose or splitting it up in multiple small doses. The rat studies I read showed that it was given with the rats chow so was just wondering how it was being utilized and how long it lasts to see if it needs to be dosed twice a day.
ATX 304
@Anthony Castore you mentioned this in the last Q&A and I was curious if this is coming here on this platform or elsewhere because I’m very curious 🧐 to hear your input.
1 like • Nov '25
@Anthony Castore Recently wacthed a video where they broke down mouse studies with the equivelant human dose of 1 gram a day. Yet everyone selling it is selling considerably less doses for considerably high prices. Is this even effective at these low doses and high prices?
Supplements and Quality - When Brand/Source Matters and When It Doesn't
Here's another group project that I discussed with @Anthony Castore and we agreed having the group work on this together would allow us to receive the best input and put together the best reference list for us all to use. Because the supplement industry is both noisy and inconsistent the distinction between quality/efficacious supplements/compounds and those that are not is often times a very difficult task: some compounds are a commodity-like (creatine monohydrate, bulk amino acids), where purity is relatively easy to achieve and there’s little advantage paying extra for a “designer” label. Other categories — especially lipids (fish oil), fat-soluble antioxidants (CoQ10, carotenoids), or bioactives with low natural stability (PQQ, Urolithin A) — live or die by formulation, raw material source, and quality control. A couple principles that might help as we consider our list: 1. Is it chemically simple or complex? Creatine: single molecule, stable, easy to verify → brand doesn’t matter much if third-party tested. Fish oil, plasmalogens, 1-MNA: unstable lipids or niche molecules → form (TG vs EE vs PC-bound) and oxidation state matter a lot. 2. Does delivery change absorption? Ubiquinol vs Ubiquinone: redox state and carrier lipids improve bioavailability. Liposomal formulations can genuinely help poorly absorbed compounds, but not everything benefits. 3. Is there independent validation? Many of the “designer” claims for things like PQQ, Apigenin, Urolithin A aren’t well-backed by head-to-head human data. In these cases, the real differentiator is whether the company does third-party testing for purity, heavy metals, and stability. 4. Follow the raw material suppliers. Most of the industry is built on the same raw material suppliers (for example, Kaneka for CoQ10, Mitopure for Urolithin A). If a product sources from a top supplier, you’re usually getting the same active regardless of label. The “Amazon brands” like Nutricost or Toniiq can be perfectly fine when they disclose sourcing and batch testing.
0 likes • Sep '25
@Drew Wurst I’ve been cycling between Jocko Super Krill, Gorilla Mind Omega Super Elixir and Carlson Krill for about a year now. Usually just whatever has a deal at the time.
The Ketone Playbook: My Go-To Protocols + Live Q&A
🚀 Ketones = Game Changer. This is the thread where I’ll drop my go-to ketone protocols ⚡️ and YOU can fire away with any questions. 💬 Comment your experiences, hacks, and questions below—let’s build the ultimate ketone resource together. 👀 Webinar coming soon… stay tuned. Practical Dosing Blueprints 1.Pre-Workout Protocol (Performance & Focus) Goal: Elevate ketones, buffer acidosis, support hydration & glucose supply. - Hydration: 500–750ml water + electrolytes (sodium 500–1000mg, potassium 200–400mg). - Bicarbonate: 0.3 g/kg sodium bicarbonate (~20g for 70kg athlete), dissolved in water. Take 90–120 min before session to minimize GI upset. - Trehalose (Carbohydrate): 15–25g as slow-release carb for sustained glycogen supply. - Ketone Ester (D-BHB/1,3-BD): 15–25ml (~7–12g KE) 10–15 min pre-warmup. Effect: Dual-fuel system (glucose + BHB), reduced acidosis, enhanced mental focus . 2.Intra-Workout Endurance Protocol Goal: Sustain metabolic efficiency, prevent bonk, extend time-to-exhaustion. - Every 60 min: Trehalose or isomaltulose: 20–30g (slow carb). Ketone Ester: 10–15ml (~5–7g KE). - Optional: electrolyte top-up (sodium/potassium). Effect: Preserves glycogen, stabilizes glucose, sustains BHB 1–3 mM . 3.Post-Workout Recovery Protocol Goal: Accelerate glycogen resynthesis, repair, and inflammation control. - Protein: 20–30g whey or EAAs. - Carbs: 40–60g high-GI glucose or maltodextrin. - Ketone Ester: 20–30ml (~10–15g KE), taken 30–45 min post-exercise (separate from carb/protein drink for maximal signaling). - Trehalose: Add 10–15g if training volume is very high or glycogen depleted. Effect: 50% faster glycogen replenishment, stronger mTOR activation, reduced inflammation . 4.Sleep Recovery Protocol (Athletes) Goal: Deep recovery, improve next-day performance. - Ketone Ester: 2.5–10ml (~1–5g KE) immediately before bed. - Optional: Magnesium glycinate/threonate for additional relaxation.
1 like • Sep '25
Being that I was on Keto for the better part of 5 years I have taken a lot of Ketone supplements. These new ketone supplements seems that are hitting the market are considerably more expensive. I take the Shift ketones I buy on Amazon usually only when I am fasting really for energy, electrolytes etc…. I have a few questions. What are all of these new Ketone brands offering in their supplements that makes them worth the extra money? Also how do you distinguish a legit brand from the rest?
The Next Generation in Metabolic Optimization: Bioglutide (aIQ-931)
At AlchemIQ Labs, we don’t just follow the science we help write it. While others speculate, we lead with rigorous research, innovative formulations, and uncompromising integrity. Our mission is simple but bold: to redefine what’s possible in cellular medicine and performance by delivering compounds that actually work, not just buzzwords. Every formula we create is grounded in peer-reviewed science. Biogoutide is a first-in-class oral therapy designed to go beyond standard GLP-1 drugs. Where current treatments often sacrifice muscle or cause harsh GI side effects, Bioglutide leverages a quadruple receptor agonist strategy, activating IGF-1, GLP-1, GIP, and glucagon receptors simultaneously. This synergy creates a powerful metabolic reset: GLP-1 + GIP → enhance insulin secretion, improve glucose control, and suppress appetite at the brain level. Glucagon receptor → boosts fat oxidation and raises energy expenditure. IGF-1 receptor → protects and preserves lean muscle mass while fat is being mobilized. Unlike injectables, Bioglutide is orally bioavailable, and is being researched as a once-daily, and able to cross the blood–brain barrier for central appetite modulation. Clinical Proof In Phase 2 clinical trials (13 weeks, 125 participants): Up to 13.8% body weight reduction at the top dose (150 mg/day).No muscle loss observed a key differentiator from GLP-1 monotherapies. Mild side effects only (nausea, diarrhea in <8%), with no severe adverse events. These results position Bioglutide as a superior alternative to single-pathway GLP-1 drugs like semaglutide and tirzepatide, especially for those prioritizing fat loss without compromising muscle integrity. Why It Matters Current GLP-1 agonists are effective but blunt tools—they drive appetite suppression and weight loss but often at the expense of lean tissue and overall metabolic resilience. Bioglutide changes the game by: Targeting multiple pathways at once for balanced, durable results. Preserving muscle through IGF-1 activation while accelerating fat oxidation.
2 likes • Sep '25
@Anthony Castore taking this post training would this be aiding in muscle building or just in muscle retention? I am in that weird faze where I am about 14% Body fat and I would like to lose a little more BF but at a 178 lbs and 5’9” i really would like to gain muscle and maintain my weight as well.
1 like • Sep '25
@Justin Graham i just ordered Orforglipron. How do you like it? I didn’t know bioglutide was going to become available or else I probably would have ordered it instead.
1-9 of 9
John Cook
2
6points to level up
@john-cook-5372
Trying to live my most optimized life.

Active 3h ago
Joined Aug 1, 2025
Powered by