@John O'Mahony What worked for me, with regard to monitoring the effects of SLU, was a wearable health monitoring device. In my case the Helio Strap which is a pretty good Whoop knock-off. It does good sleep tracking and it also keeps tabs on your SpO2 and heart rate during the day. It has a feature it labels PAI (personal activity index maybe?) that will give you a daily score based on your activity. The score mostly seems to be increased by getting into and staying in aerobic heart rate ranges for periods of time. The "wow" realization for me with SLU happened by accident one day about a month ago while checking this metric (which I don't always even do). That day I had decided to take my biggest ever dose of SLU since I was nearing the end of my bottle (a liquid suspension). Up to that point I had taken anywhere from 500mcg to 2-3mg daily and up to 20mg a couple of times. I was on the fence about whether it was having beneficial effects for me. Sometimes I'd sweat a little more readily working out. With one of the larger doses I had felt a 'vibration' sensation throughout my body when laying down for bed that night. Well, this particular dose would have been somewhere in the 100mg range. I took it fasted, first thing in the morning with most of my other supplements. The day went by as normal. I didn't feel any different--I had kind of forgotten about the big dose. That night I went and played two hours of 4-man sand volleyball. This was a weekly thing for me on that day of the week. There was nothing especially different about this day. My sleep had been about the same as the week prior. My nutrition roughly equivalent. My workday hadn't been vastly different. The week before my PAI score had been in the mid twenties, which was really good, one of my higher single activity PAI scores I had achieved. My heart rate at sat in the mid 140s for a while during play (I'm 48, for reference). 1.5 hours in the gym doing what I would call a somewhat intense workout usually gets me about a +10 on PAI, and half of that is my time on the hack squat. Well, this night my PAI score was in the mid 60s. My heart rate had been in the low 170s for a little bit. I hadn't noticed it at all during play. I felt great. But now I know, SLU really does work.

Drew is a great host. Maybe a little on the sycophantic side with his guests at times, but very respectful and always lets his guests get everything they want to say out before interjecting with a good guiding follow-up question or anecdotes about what was just said. This was a very good episode.

After you've had a long time to reflect on your experience with Trekrezan, what are your thoughts on it?

@Brady Nielson I'm with your wife on this one. I generally gobble up as much content about this stuff as I can but I tried to watch a couple of his videos and couldn't make it very far. I can't take his try-hard tough guy schtick seriously. @Anthony Castore Dean St. Mart on the most recent metabolic round table with Steve and Kurt was red team/blue teaming this subject and agreed with what you said from an "on paper" perspective but went on to say that micro dosing might have better real world results for some because underground GLP-1 meds, whilst generally having close to the advertised dosing of included GLP-1 formulation, could differ significantly in the rest of the formulation such as carrier chemicals and what-not and that could actually effect the half-life vs. the pharmaceutical version.

@John Cook It's hard to conclusively say how a mouse dose should convert to human dosing. In a deep dive about clenbuterol I listened to recently they said that using the mouse to human dosing conversion in the animal studies they conducted with clen it would have come out to 10mg daily for humans. We know enough about the effect clen has on humans to assume most peoples hearts might explode at that dose.

@Joe P Gemini seems pretty confident that it has a half-life in humans of 10-12 hours so dosing multiple times per day seems unnecessary to me.