SLU - Bioavailable and Safe or NOT · Castore: Built to Adapt

SLU - Bioavailable and Safe or NOT

Good morning everyone!!

This came up in one of the groups I am a part of. I wanted to share it here to get Anthony and anyone else who we look to as an expert in this subject matters opinion. I know Anthony’s research contradicts the fact that the member of my group is saying SLU is not bioavailable. But the members research and thoughts are concerning. Can everyone share your thought on this and if there is any validity. I know many a RS has had great results with this compound. The below is copied from the group.

SLU-PP is hydrophobic and must be dissolved in chemicals not safe for injection.

For oral use, early member tests suggest that SLU-PP does not survive stomach acid and may break down into unsafe byproducts, including hydrazine-like fragments, which should not be ingested by humans.

Initial data from Jano on the degradation testing for SLU-PP-332 in simulated stomach acid.

https://janoshik.com/tests/87013-SLUPP332_PDDAB_DMSO_HCL_NAOH_H2O_SAMPLE_A_HFW3ZIDG7YN1

https://janoshik.com/tests/87014-SLUPP332_PDDAB_DMSO_HCL_NAOH_H2O_SAMPLE_B_XXH9UD6N8HGF

Starting reagents were SLU-PP-332 and p-dimethylaminobenzaldehyde (p-DAB) in DMSO.

Sample A was titrated to pH 1.5 with 0.1M hydrochloric acid in water and heated to 37C for 2 hours with constant stirring, then neutralized to pH ~6 with 0.1M sodium hydroxide.

Sample B used the same starting reagents, but the heating step was performed without the addition of HCl. Instead, a mixture of 0.1M HCl+NaOH titrated to pH ~6 was added after heating to match the final dilution of sample A. Calculated dilution btw was 1.8mg/mL SLU-PP-332, looks like I got pretty close as sample B tested at 1.719mg/mL. The goal was 2mg/mL but titration is hard and I'm out of practice.

Potential breakdown products of SLU-PP-332 are expected to be: 1-napthaldehyde, 4-hydroxybenzohydrazide (4-HBH). The latter can further break down to 4-hydroxybenzoic acid and hydrazine, which will complex with p-DAB to form the yellow azo dye p-dimethylaminobenzalazine. There may also be some complex formed between p-DAB and 4-HBH, I couldn't find this discussed in any literature I could find, though.

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