Nuanced question. Dihydroberberine or Metformin when considering glucose/lipid modulating effects for longevity around a protocol involving strength training, HIIT, and some zone 2. I know the research tends to describe Metformin being more detrimental to exercise adaptations, but is this known similarly with DHB? I know Dr. Seeds is not a fan of Metformin d/t some negative mitochondrial changes that can occur.