An Orally Active ERR Agonist, SLU-PP-915, Enhances Aerobic Exercise Capacity (1 December 2025) The authors stress that 332 is NOT orally bioavailable. "We previously developed a ERR pan-agonist, SLU-PP-332 (332), which improve aerobic performance in mice but lacks oral bioavailability. Here, we characterize SLU-PP-915 (915), a chemically distinct ERR pan-agonist that is orally bioavailable and exhibits potent in vivo exercise mimetic activity." Who can help to get the full paper and interpret the findings? Specifically , is there any new data on how much exactly SLU-PP-332 orally bioavailable (%) ?

@Anthony Castore Your boy has been on my mind. Do we have any updates? Hope he’s doing amazing and recovering?!!! 🙏🏼💕 Avocado, my Mal, isn’t fully back, but a lot better. Appears to me it is a strain of some sort in his left hind leg. The CBD, love and attempt to keep him from being his spunky self seem to aid toward healing… 🙏🏼

Last night, I woke up to something that shook me in a way I haven’t felt in a long time. My bulldog Jeter, who’s ten now and basically my shadow, was shivering on the inhale while he slept. At first I thought maybe he was cold, or dreaming. Bulldogs dream with their whole soul, so that wasn’t unusual. But something felt off. The tremor wasn’t rhythmic like dreaming. It was sharp, almost like a nerve misfiring. When he got up from bed to walk to another room, he seemed weak like his legs weren’t receiving the normal signals from his brain. His shoulders and legs trembled slightly, his paws looked unsure beneath him, and he kept repositioning like he couldn’t get comfortable. That’s when my stomach dropped. I scooped him up, put him in the car, and Julie and I drove straight to MedVet. If you’ve ever loved a dog deeply, you know that feeling where you go from half-asleep to wide awake with one single thought: “Please let him be okay.” At MedVet they gave him a ketamine and methadone shot for pain, and they suspected a disc issue in his spine. They didn’t run an MRI that night, so we were left with the kind of diagnosis most dog owners get at first: “Likely disc compression, monitor closely.” In other words, an entire universe of things could be happening under the surface. When we finally got back home, Jeter was sedated, wobbly, and tremoring. He was trying to be strong bulldogs have a level of pride that honestly rivals ours—but he was struggling. And in moments like that, both as a practitioner and as a dog dad, you are forced to sit between two worlds: the scientific understanding of what’s happening, and the emotional weight of watching someone you love suffer. That’s what inspired me to write this for you today not just to share the story, but to teach you what’s actually going on inside a dog’s body when a disc bulges, why the symptoms show up the way they do, and how targeted regenerative peptides like Pentosan, ARA-290, TB-500, BPC-157, and SS-31 can create a powerful recovery pathway when used correctly.

Thanksgiving has a way of slowing life down just enough for you to actually notice what’s been happening underneath all the noise. You sit with people you love, share a big meal, breathe for the first time in weeks, and suddenly you’re able to feel things you usually ignore. Maybe this year, in that moment of stillness, you noticed something strange: your body feels strong, your training is dialed in, your glucose looks perfect… but your brain doesn’t match how good the rest of you feels. Maybe you felt foggy after a meal, mentally slower than usual, overwhelmed for no reason, or just “not as sharp,” even though everything on paper says you’re metabolically healthy. If that sounds familiar, you are not alone and there’s a real physiological explanation behind it. How can someone be physically insulin-sensitive yet mentally sluggish? How can your muscles get the fuel they need while your brain feels like it’s running on fumes? This article is written for you, to answer exactly that question. Central insulin resistance is the phenomenon where your brain becomes insulin-resistant even when the rest of your body remains highly insulin-sensitive. Many people experience this as a strange mismatch: they feel physically strong, metabolically healthy, and steady during training, yet their cognition feels foggy, slow, unpredictable, overwhelmed, or “under-powered.” This article explains why that happens, what the mechanisms are, how to recognize the patterns, and how to fix them, using simple language without sacrificing the biochemical accuracy that clinicians and experts expect. The first thing to understand is that the brain handles insulin differently from the rest of the body. Your muscles and liver respond directly to insulin in the bloodstream. The brain does not. For insulin to have any effect in the brain, it must cross the blood–brain barrier, bind to receptors on neurons, activate the PI3K-Akt pathway, and allow neurons to take up and use glucose. If anything disrupts that sequence, neurons will be under-fueled even if the entire rest of the body is functioning perfectly. This is why someone can have excellent fasting glucose, low insulin, perfect CGM curves, and still feel terrible cognitively. The brain can become insulin-resistant before the body gives any signal.

I was wondering if you have archives of your articles? I just read this article from the SR about VIP and I cannot tell if it is good or bad (after already placing an order). So looking for more clarity about using it.