Cholesterol: Part 2: The Great Statin Debate
Part 2: The Great Statin Debate Benefits, tradeoffs, and the dangers that are often glossed over If cholesterol is the most misunderstood molecule in modern medicine, then statins might be the most emotionally charged prescription on the planet. I personally believe, that statins are chronically over-prescribed and under-explained, and can be potentially dangerous when misused, overused, or used to avoid addressing the real underlying issue. In the Bedrock/Rooted Faith lane, we believe in Informed consent. Context. Stewardship over fear. Statins come with tradeoffs—and too many people never hear the full story. This article is about the dangers that often get minimized—so you can ask better questions and make a decision that fits you. The dangers and tradeoffs that often get glossed over when speaking with your prescribing physician: 1) Muscle symptoms and exercise intolerance (SAMS) Muscle pain, cramps, weakness, and fatigue are among the most common reasons people stop statins—whether due to the statin itself, other causes, or a mix (including nocebo effects). Major expert panels still treat SAMS as a real clinical issue and provide guidance for evaluating it. PubMed+2OUP Academic+2 Statins cause muscle pain (myalgia) likely due to disrupting muscle cell energy (reducing CoQ10), causing calcium leakage for cell function, potentially affecting muscle proteins, and increasing sensitivity, says the Mayo Clinic, Verywell Health, Healthline, and the National Institutes of Health. Key theories on why statins cause pain: - Coenzyme Q10 Depletion: - Calcium Leakage: - Muscle Membrane Instability: - Inflammation & Protein Issues: