A Client has had a terrible time lately with gout flare-ups, and his physician's response is higher and higher doses of prednisone to mitigate discomfort. Nothing has been done to potentially address causation (beyond the typical nutritional guidelines) or to explore better ways to prevent or manage acute onset, other than pharmaceuticals - which opens a plethora of other cans of worms, especially long term. I can't help but think that certain peptides might serve him better in managing his acute episodes or even more systemically? He is already taking BPC-157 orally for his acid reflux, which works magic for him, and is open to exploring others. Recently, I came across a few papers that reference studies on "rice-derived polypeptide" (RDP2), which have shown promise in treating hyperuricemia and gout attacks. However, I can't seem to locate information on whether this is something that is available and/or how successful it has proven to be, if so? Does anyone have insight on this? Besides that, other considerations that come to mind for me are KPV, VIP, and/or maybe TA1, GHK-Cu? On the supplementation end of things, the known players: Curcumin, Ginger, Bromelain, Quercetin, Krill Oil, Magnesium Glycinate, B-Complex? Gratitude in advance for any feedback and ideas shared so he can get started on a small protocol.🙏

Hello everyone! 👋 I'm diving into the world of ketone powders 🏊‍♀️ and would absolutely love your collective wisdom! 🧠✨ Has anyone here had any experience with products like the ( Keto Science Real Ketones Powder Passion Fruit ) ? 🥭 I'm super curious about a few things: - Taste 😋 (Is it delicious? Is the passion fruit really passion fruit? 🤔) - Effectiveness 💪 (Did you feel a difference? ⚡️) - Any tips or tricks you might have! 🙏 Since my background is in green drink manufacturing 🌿🍹 (I've even worked with drink manufacturers! 🏭), I'm feeling confident I can develop a really effective and super palatable ketone intake solution! 🎯💯 Any insights 💡 from your personal experiences would be incredibly helpful as I start mixing and formulating! 🧑‍🔬 Thank you so much in advance! 🙌 Let's chat keto! 💬

I’m currently working with someone who is experiencing symptoms that seem to be connected to spirochete borrelia. From what I understand, this can show up in many different ways and can be quite challenging for the person going through it. I realize that not everyone here may be a professional in this specific area, but I thought this community could be a thoughtful place to begin gathering ideas and perspectives. I’m really interested in hearing from anyone who may have experience—whether personal, through supporting a loved one, or from study—about what approaches or practices have been helpful in easing symptoms and supporting the healing process. Sometimes the best insights come from shared stories, small lifestyle adjustments, or supportive resources that aren’t always obvious at first. If you know anything about spirochete borrelia, or even if you’ve found general methods of supporting the body during times of imbalance, I would be grateful to learn from you. The goal is to create a supportive path forward for this person, and every bit of knowledge can make a difference.

Gamma waves (30–100 Hz) are high-frequency rhythms generated by parvalbumin-positive interneurons that synchronize distributed cortical activity. They ride on theta rhythms in a process called theta–gamma nesting, which helps the brain tag when to encode versus retrieve information. Gamma provides the bandwidth for complex integration, fluent improvisation, and insight. These oscillations are metabolically expensive, requiring tight mitochondrial coupling, strong redox control, and support from BDNF/TrkB and CREB-driven plasticity programs. Gamma is primed by novelty learning such as music, language, or complex sports, entering flow states where skill meets challenge, and by physiological readiness with adequate sleep, DHA, magnesium, and sometimes ketone availability. Emerging human studies suggest ketone supplementation can support cognition and cerebrovascular function in certain contexts. Gamma is sabotaged by sleep loss, neuroinflammation, sedentarism, and low BDNF states. Tools that can support Gamma include photobiomodulation (e.g., 810 nm light) earlier in the day to improve mitochondrial tone, novelty practice blocks of 20–40 minutes per day, and situational use of ketone esters on heavy integration days. Tracking Gamma strength can be done indirectly by monitoring time-to-competence in new skills, spaced-retrieval recall, and noting “click” moments, all while ensuring deep sleep is sufficient. A quick 5-minute Gamma protocol before learning is to review yesterday’s practice for one minute, perform three minutes of focused micro-drill, then immediately recall or write back for one minute. A real-world example is a jazz musician who practices scales in Alpha, drills transitions in Beta, repairs through Delta sleep, and then steps into Gamma during improvisation on stage their bandwidth for mastery is trained, not accidental.

When people hear about drugs or gene therapies that block myostatin, it can feel far removed from daily life. But what if there were ways to nudge this brake system with things already in your kitchen or supplement cabinet? While no diet or supplement will “turn off” myostatin the way a lab-designed antibody can, several foods and compounds have been studied for their potential to lower myostatin activity or tilt the balance toward more muscle-friendly signals.Let’s start with diet. Calorie restriction, especially versions like the DASH diet, has been shown in older adults to reduce circulating myostatin levels. The theory is simple: by lowering inflammation and improving metabolic efficiency, the body doesn’t feel the need to clamp down as hard on muscle growth. Protein intake is the most obvious lever people ask about, but here the data is mixed. High-protein diets build muscle, yes, but the direct effect on myostatin expression is inconsistent across studies.Supplements give us more specific leads. Creatine, one of the most researched compounds in sports science, has been shown to blunt myostatin’s activity when combined with resistance training. It not only preserves muscle but also lowers myostatin in serum. Epicatechin, a flavonoid found in dark chocolate and green tea, increases the ratio of follistatin to myostatin. Follistatin is essentially the antagonist to myostatin—the tug-of-war partner that pulls the rope toward growth instead of restraint. In practice, this may support hypertrophy, though human studies are still small.Vitamin D also enters the conversation. In populations with deficiency, supplementation has been shown to reduce myostatin mRNA expression. That means vitamin D may help redirect calories toward supporting muscle instead of being stored as fat, but the effect depends heavily on baseline levels. Quercetin, another plant compound found in apples and onions, has demonstrated in vitro the ability to inhibit myostatin and enhance satellite cell activity, which is important for muscle repair. Finally, Fortetropina supplement derived from fertilized egg yolks has reduced circulating myostatin by about 20 percent in human trials, making it one of the more direct nutritional approaches on record.