Peptides are often treated like supplements you can stack for convenience. One for repair, one for metabolism, one for inflammation. That mindset leads people to assume they can simply mix peptides in the same syringe and inject once. The problem is peptides are not pills. They are fragile, information-carrying molecules whose behavior is governed by physics, chemistry, and biology at the same time. A peptide is not just a chain of amino acids. In solution it exists as a three-dimensional structure held together by weak forces like hydrogen bonds, electrostatic interactions, and hydrophobic effects. These forces are highly sensitive to the environment. Small changes in pH, ionic strength, or solvent conditions can change the peptide’s shape, stability, and behavior. When a peptide is manufactured, it is stabilized in a very specific formulation. That formulation controls pH, charge, ion balance, and solubility so the peptide stays folded correctly and remains biologically active. When you mix two peptides together, you destroy that controlled environment and create a new, untested chemical system. One of the first things that goes wrong is charge balance. Peptides carry electrical charge depending on pH. That charge helps keep molecules from sticking to each other. Mixing peptides can shift pH just enough to reduce repulsion between molecules. When repulsion drops, attraction wins, and peptides begin to stick together. Ionic strength matters too. Mixing solutions often increases ion concentration, which compresses the electrical “buffer” that keeps peptides apart. This allows molecules to drift close enough for hydrophobic regions to interact. Water dislikes exposed hydrophobic surfaces, so peptides clump together to lower free energy. This is basic solution physics. Once aggregation starts, it accelerates. A few misfolded molecules form a nucleus, which seeds further aggregation. Early clumps may be invisible, but they still matter. They reduce the amount of active peptide, alter absorption, and change signaling behavior.

Ok, I feel like I have some pretty good resources into the peptide world. I have a mastermind with a well known lawyer. I’ve asked about what’s up and coming in 2026 and nothing concrete has been stated. YET, open social media and everyone is talking about having to stock up on GLP-1s. Is this valid/legit or is this just classic gate-keeping, fear-based marketing at its best. Seems the only ones pushing this agenda are ones ironically selling research peptides or alternatives. And I even sell research peptides but I will not tell my customers things I can’t substantiate. What am I missing? I know there’s some proposed legislation (i.e. Safe Drug Act) but that hasn’t been passed and isn’t even close from what I’ve been told. The truth is, research companies have always been under scrutiny, so that’s not new, so what is this fear that’s being perpetuated? Thanks!

In the latest DDT Method podcast with @Anthony Castore , Anthony discussed NAD supplementation. What I found interesting is that Anthony seemed to be against NAD supplementation via NAD+ and its precursors if I understood correctly, and a more appropriate approach would be to instead use a combination of 5 amino and 1MNA. He suggested using 5 amino pre workout and 1MNA on rest days in the evening. Anthony - would you be able to expand on your thoughts regarding NAD supplementation given it seems like a given in the longevity community that you supplement with NAD+ (injection or IV) or its precursors (NMN, NR).

I am one of those people who on day one when I used Metashred (BAM/SLU combo) it sent me to the ER. Tried again a week later and although I was able to stay away from the ER it wasn't a pretty couple of hours. I decided instead to split up the two (SLU on training days and BAM on rest days). Been using SLU for a while at various dosages with no issues. For BAM, the capsules I have are 15mg. Took my first dosage yesterday on my rest day without issue. Is there a dosage I should be working up to?

Cerebrolysin for better brain function — has anyone tested it, and what are the recommended dosages and protocols?