We are officially closing in on 1000 members inside the Built To Adapt community and I honestly can’t thank you guys enough for what this has become. What started as a place to have better conversations around cellular medicine, strength training, recovery, performance, and health has turned into one of the most thoughtful communities I’ve ever been part of. Some of the best conversations I’ve had this year have happened inside this group. I’ve watched people completely rethink how they approach recovery, training, supplementation, metabolism, and long-term health. More importantly, I’ve watched people learn how to think instead of just what to think. Truthfully, I think I’ve learned more from this community than I’ve taught. That’s the part I value most. This was never supposed to be me talking at people. It was supposed to be curious people learning together, challenging ideas together, and helping move the field forward together. We built this together. Now I have one favor to ask… We’re getting very close to 1000 members and I would genuinely love to cross that milestone before June. If this community has helped you, challenged you, or made you think differently, please invite ONE person who you think would love deeper conversations around health, performance, training, recovery, and human optimization. Invite a coach.Invite a clinician.Invite a biohacker.Invite someone tired of surface-level health advice. There is absolutely no cost to join. Even when the paid tier launches in June, this free community will always exist and I will continue posting free articles, education, and content here. The biggest benefit to me is simple:More minds.More discussion.More questions.More opportunities for all of us to learn together. My goal is to continue building THE place people can come for clear explanations and actionable insights on how to leverage cellular medicine and strength training to take agency over their health and performance. As a thank you, once we cross 1000 members I’m going to host a completely FREE live webinar:

Is reconstituted AOD-9604 NOT supposed to be refrigerated? I have zero issues when I reconstitute it: no clumping, gelling, nothing. But after a few days, the liquid starts to become more viscous...thick. Is this normal? I don't have any problems drawing it up and injecting it still. I just thought it was weird that it changes! Please note that I do reconstitute with 1mL of acetic acid and 1mL of bac water.

This community exists to correct a problem I see every day: smart, motivated people making avoidable mistakes because they are reacting to information instead of reasoning through it. Everything here is built around clear thinking, proper sequencing, and confident restraint. There are several ways to engage. Each one is designed for a different level of responsibility. The question is not whether to invest. The question is where you are right now. The Cellular Intelligence Circle For Orientation, Context, and Staying Current The Circle is where confusion gets resolved before it turns into action. This is the right place if you want to: - Understand emerging science without overreacting to it - Learn how decisions are actually weighed - Separate signal from noise - Avoid unnecessary intervention It is a content-first environment designed to compound over time. Membership provides access to a growing, curated body of work that functions as a reference library, not a feed to keep up with. Inside the Circle: - Peptide of the Month (mechanism, context, restraint) - Protocol and case reasoning breakdowns - Science article reviews focused on interpretation, not hype - Monthly live Q and A - Periodic synthesis webinars The Circle is not coaching. It is not protocol delivery. It is where judgment is built. Pricing - $79 per month - $219 for three months - $499 for twelve months This level is appropriate when your primary goal is orientation, understanding, and staying sharp. One-Time Consultations For Specific Decisions. Consultations exist for moments when a decision needs to be handled correctly. They focus on: - Identifying what actually matters - Removing unnecessary complexity - Clarifying what not to do Pricing - One hour consultation: $350 - One hour consultation with follow-up: $500 This option makes sense when a single decision needs careful thought. Ongoing Advisory Core For Continuity and Guardrails. This is for people who no longer want to think through complex decisions in isolation.

What would be a recommended protocol for running tirz alongside reta? I'm taking reta once a week at 3.5mg and looking to ramp up to 4mg soon. I'm already having better success with the higher dosage but I'm looking for additional help curbing the food noise and suppressing cravings. Thanks in advance!

I’ve talked about this a few times before, but I know there are still plenty of questions around it so I wanted to take another shot at clearly explaining the reasoning behind my answer. The case against higher doses of SLU-PP-332 starts with first principles: this compound works as a signaling cue, not a substrate to be “pushed” toward saturation. In cell systems and animal models, SLU-PP-332 appears to activate the estrogen-related receptor (ERR) program with PGC-1α coactivation, shifting transcription toward fatty-acid oxidation, oxidative phosphorylation, and mitochondrial quality control. That kind of pathway is amplifier biology: a small receptor-level nudge fans out into many downstream genes and post-translational switches. In such networks, more ligand does not linearly equal more benefit; it often crosses into different biology entirely, including compensatory braking and desensitization. Think of it like tapping a conductor’s baton to set tempo versus throwing a bigger baton at the orchestra. The first coordinates; the second creates noise and reflexes you didn’t intend. A key downstream branch of the ERR/PGC-1α program is modulation of uncoupling proteins. Mild, context-appropriate uncoupling in UCP2 and UCP3 can lower electron pressure, trim reactive oxygen species, and improve metabolic flexibility under load. But pushing the axis hard increases the probability of off-site expression and activity in UCP4 and UCP5, which are enriched in neurons and glia. Excess uncoupling in those tissues risks local ATP shortfall where energy security is non-negotiable. In brain and autonomic circuits, too much leak across the inner mitochondrial membrane can force compensatory hypermetabolism to maintain voltage, distort calcium handling, and disturb neurotransmission timing. At the organism level, that looks like brain fog, dysautonomia, sleep fragmentation, and reduced stress tolerance exactly the systems you don’t want to pay for marginal fat-loss gains. Mechanistically, high-dose signaling also raises the odds of maladaptive redox and substrate partitioning. ERR/PGC-1α drive beta-oxidation and electron delivery to the respiratory chain. If you layer that on top of exercise, fasting, thyroid augmentation, or catecholamine tone, you can overshoot electron influx relative to complex-level throughput, increasing retrograde signaling and forcing the cell to dump potential as heat via uncoupling. At low dose this can be hormetic and helpful. At high dose, it can flatten the ATP/ADP ratio, trigger AMPK hard, suppress mTORC1 anabolics, and blunt hypertrophy. In muscle, that shifts toward more oxidative phenotype at the expense of contractile remodeling; in the heart, it risks energetics imbalance that the sinoatrial node and conduction system must buffer beat-to-beat.