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3 contributions to Castore: Built to Adapt
WHY MIXING PEPTIDES IN THE SAME SYRINGE BREAKS THE RULES OF PHYSICS AND BIOLOGY
Peptides are often treated like supplements you can stack for convenience. One for repair, one for metabolism, one for inflammation. That mindset leads people to assume they can simply mix peptides in the same syringe and inject once. The problem is peptides are not pills. They are fragile, information-carrying molecules whose behavior is governed by physics, chemistry, and biology at the same time. A peptide is not just a chain of amino acids. In solution it exists as a three-dimensional structure held together by weak forces like hydrogen bonds, electrostatic interactions, and hydrophobic effects. These forces are highly sensitive to the environment. Small changes in pH, ionic strength, or solvent conditions can change the peptide’s shape, stability, and behavior. When a peptide is manufactured, it is stabilized in a very specific formulation. That formulation controls pH, charge, ion balance, and solubility so the peptide stays folded correctly and remains biologically active. When you mix two peptides together, you destroy that controlled environment and create a new, untested chemical system. One of the first things that goes wrong is charge balance. Peptides carry electrical charge depending on pH. That charge helps keep molecules from sticking to each other. Mixing peptides can shift pH just enough to reduce repulsion between molecules. When repulsion drops, attraction wins, and peptides begin to stick together. Ionic strength matters too. Mixing solutions often increases ion concentration, which compresses the electrical “buffer” that keeps peptides apart. This allows molecules to drift close enough for hydrophobic regions to interact. Water dislikes exposed hydrophobic surfaces, so peptides clump together to lower free energy. This is basic solution physics. Once aggregation starts, it accelerates. A few misfolded molecules form a nucleus, which seeds further aggregation. Early clumps may be invisible, but they still matter. They reduce the amount of active peptide, alter absorption, and change signaling behavior.
0 likes • 3d
@Anthony Castore This is an eye-opener. I’ve heard Dr. Trever Backkman warn about this repeatedly, but seeing it broken down by the physics of aggregation and charge balance really drives it home. It’s wild how many big names still push pre-mixed vials like ‘GLOW’ despite the chemistry saying otherwise. This leads to my biggest concern regarding delivery methods, specifically, nebulizers. You mentioned that 'agitation' and 'surface exposure' degrade peptides. Since a nebulizer works by violently agitating a solution into a mist (creating massive surface area), does this essentially destroy the peptide before it even enters the body? I have my father nebulizing Cardiogen right now. Since bioregulators are smaller chains, are they robust enough to survive that physical stress, or am I making the same mistake as the 'mixing' crowd, prioritizing convenience over molecular integrity?
Is EWOT worth it or a waste of money?
I'm convinced about the benefits of BFR and CO2 therapies and I own both devices. However, for someone who isn't an athlete and just wants to have physical and mental energy throughout the day, is EWOT the best addition or a waste of money? I searched for EWOT here and it doesn't seem like people are talking about it.
🔥 Big news, friends—our community is about to level up in a massive way
📌 First up… the votes are in for our SLU-PP-332 Webinar!🗓 Saturday, August 23rd at 10 AM ESTThis isn’t just another presentation—this is the deep dive. In one session, you’ll go from curious to industry fluent. We’ll bust the myths, show you exactly what SLU-PP-332 is, how it works, when to use it (and when not to), and walk through every pathway and mechanism that matters. No stone will be left unturned, and you’ll leave with the clarity and confidence to make informed decisions that maximize health outcomes. 📌 Next up… Case Breakdown LIVE🗓 Monday, August 25th at 5 PM ESTI’m pulling back the curtain on my own protocol—explaining my entire thought process, the “why” behind each step, and how to approach your own situations with system-based thinking. This will become a monthly tradition where members can submit their own cases for us to work through as a group. The goal? Tap into the brainpower of this community and learn from each other’s unique perspectives. 🌟 Member of the Month is launching!Every month, I’ll randomly choose one of you for a short interview and spotlight. This is about celebrating you—your story, your journey, and how we can better support one another. Got someone you’d love to see featured? Send me your suggestions (just not yourself 😉). 💥 This community stays FREEI love the energy, curiosity, and generosity here. All I ask—help me hit 1,000 members. The more like-minded people we have, the faster we all grow. Invite your friends, colleagues, and anyone who loves this work. 🛒 Buyers Club is here My first pick: Kinetik Pro. Every two weeks, I’ll coordinate a group order. Depending on participation, we’ll score 10–25% off. I will put a seperate post up on this soon but ofr now you can message me direct. When we have a system dialed in I will add these other lines including access to: BodyBio, Metagenics, Thorne, NutraDyn, Orthomolecular, 1-MNA, NuBioAge, Prodrome, Healthgevity and more to come! 🎥 Recordings & ResourcesAll webinars, Q&As, and courses will be available for $39.99 each, OR… grab a $200/year subscription and get everything—plus a monthly ebook packed with deep-dive, actionable protocols. That’s over $760 in savings while directly supporting the growth of this community.
1 like • Nov '25
@Anthony Castore Did you end up launching this? Not sure how to sign up.
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Ammar M
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3points to level up
@ammar-m-3616
Hungry for knowledge, always learning.

Active 8h ago
Joined Nov 27, 2025
Michigan
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