Great news: hormone replacement therapy does not increase cancer risk!
A major Danish study finds no excess mortality, even with long-term use, and signals real benefits after surgical menopause. The study, Menopausal hormone therapy and long-term mortality: nationwide, register-based cohort study, is from Denmark, where they have robust registries they can mine and produce far better observational studies than we can in America. Over 800,000 women were included, with an average follow-up of 14.3 years. Just over 100,000 women filled at least one HRT prescription, more than 15,000 took HRT for 5-10 years, and over 7,000 women had 10 or more years of HRT use. This really shows the power of well-managed databases, because these numbers are just not achievable in a clinical trial. With 12 million person-years of follow-up, the investigators found no “epidemiological evidence of excess mortality following menopausal hormone therapy use. Specifically, they did not see an increase risk for female cancer such as breast, uterine, ovaries, etc. That has been the concerns for the last 30 years is that HRT could increase the risk of certain cancers. But this study, along with several others published in the last 5 years or so, has confirmed that HRT does not cause cancer! I have to mention that HRT was done using bio-identical hormones, but not the synthetic estrogen or progesterone, which could actually increase the risk of cancer.