Vns: Promising Results For Treatment-Resistant Depression Highlighted

Vagus Nerve Stimulation (VNS) and Treatment-Resistant Depression.

The RECOVER trial utilized VNS for TRD over two years.

A 52-week, double-blind phase was followed by a 104-week extension.

Active VNS yielded 27.4% remission vs. 12.3% with sham at 52 weeks.

After 104 weeks, remission reached 45%, with a 67% response rate.

VNS reduces IL-6 and TNF-α, and upregulates hippocampal BDNF.

VNS enhances synaptic plasticity and improves HRV.

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This group is designed for the discussion of the Vagus Nerve, techniques to stimulate it, and the benefits of doing so.

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