Harvard researchers discover how gut bacteria control blood sugar through the liver

New Harvard research in Cell Metabolism identified specific metabolites that travel from the gut through the portal vein to the liver, where they influence insulin sensitivity. Researchers detected 111 metabolites in healthy mice, but when obesity-prone mice ate a high-fat diet, that number dropped to 48, showing how diet shapes which metabolites reach the liver.

When they exposed liver cells to a single metabolite (mesaconate), it improved insulin signaling and regulated genes involved in fat metabolism. This validates what I've said for years: the gut is a metabolic command center. The microbiome produces compounds that directly regulate how the liver handles energy, creating a mechanistic link between gut health and metabolic disease.

This isn't correlation—it's a mechanism, opening doors to new strategies for obesity and type 2 diabetes.

As they say, everything starts in the gut! Healing the gut is the foundation of health! Eat oranic food, drink plenty of water with electrolytes, detox your body, get good sleep of night and handle your stress. These are the pillars of optimal health!

2 comments