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https://youtu.be/UIBT-izj_CY CALMING EFFECTS OF GLYCINE (The Sleep-Supporting Pathway) Overview For most individuals (85–95%), glycine produces a calming, sleep-supporting effect when taken at night.This effect is driven by its influence on body temperature regulation, circadian signaling, and inhibitory neurotransmission. ✔️ 1. Lowers Core Body Temperature (CBT) - Glycine activates NMDA receptors in the suprachiasmatic nucleus (SCN). - SCN sends signals to increase skin blood flow, causing heat to leave the core. - This drop in temperature is a primary biological trigger for sleep onset.Outcome: Faster falling asleep, easier sleep transitions. ✔️ 2. Strengthens Circadian Output - Glycine increases SCN neuropeptides: AVP and VIP. - These reinforce nighttime signaling without shifting the circadian clock.Outcome: More stable sleep cycles and fewer awakenings. ✔️ 3. Enhances Inhibitory Tone - Glycine acts as an inhibitory neurotransmitter in the spinal cord and brainstem. - Promotes muscle relaxation and reduces physiological arousal.Outcome: A “calm body” sensation conducive to sleep. ✔️ 4. Improves Glutathione Production (Long-Term Effect) - Glycine is essential for glutathione synthesis, often the rate-limiting component. - Higher glutathione → lower oxidative stress → healthier hypothalamic and brainstem sleep circuits.Outcome: More restorative sleep and higher morning alertness. ✔️ 5. Clinical Results (3 g before bed) Peer-reviewed trials show: - ↓ Sleep latency (fall asleep faster) - ↑ Sleep efficiency - ↓ Fatigue & daytime sleepiness - ↑ Morning alertness, energy, and cognition - No major adverse effects at studied doses Ideal Candidates for Calming Effects - People with nighttime overheating - Trouble falling asleep - Light sleep or early awakening - Age-related sleep decline - Stress-induced shallow sleep Overall:Glycine supports sleep by working with the body's natural nighttime biology, rather than sedating the brain—making it one of the safest and most physiologically aligned sleep nutrients.

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