Once you hit 40, your body doesn’t suddenly fall apart. What actually happens is more subtle and more dangerous. Things slowly drift. Energy drops. Recovery takes longer. Weight sticks easier. Sleep isn’t the same. Bloodwork starts moving in the wrong direction before you “feel” anything is wrong. From a medical and data-backed perspective, three issues consistently rise after 40: 1. Cardiovascular health (especially blood pressure). High blood pressure becomes extremely common in your 40s and 50s. Most people don’t notice it until it becomes a bigger problem. SSRP angle: improve cellular energy + vascular signaling + repair environment. Peptides Dr. Seeds / SSRP commonly discusses in this orbit: - GLP-1 pathway peptides / GLP-1 RAs (clinically used medications) — Seeds emphasize GLP-1s beyond weight loss and diabetes, including relevance to heart disease. SSRP Institute - MOTS-c + SS-31 — SSRP materials explicitly discuss “mitochondrial peptides like MOTS-c and SS-31” in the context of cellular energy balance and repair. SSRP Institute - Thymosin Beta-4 (TB4) — Seeds’ text references TB4 in relation to angiogenesis and cardiac repair research. Rapamycin News Important note: blood pressure management still starts with sleep, stress, salt/potassium balance, and consistent zone-2 walking. 2. Metabolic dysfunction (weight gain, insulin resistance, prediabetes). Your metabolism becomes less forgiving. Sugar hits harder. Fat loss slows. Inflammation goes up. This is the foundation for many chronic diseases later in life. SSRP angle: regulates glucose signaling, appetite signaling, and cellular energy pathways. Peptides Dr. Seeds / SSRP commonly discusses in this orbit: - GLP-1 peptides / GLP-1 RAs — Seeds cover GLP-1 biology and its glucose-lowering + weight-loss relevance in Peptide Protocols. Rapamycin News - MOTS-c + SS-31 — again, SSRP frames these as mitochondrial support peptides tied to energy balance. SSRP Institute - TB4 — Seeds’ references include a potential role discussion in fatty liver disease literature. Rapamycin News