I finally bit the bullet and ordered some Retatrutide, 10mg. Have been really curious to give it a try, but I am a real chicken when it comes to needles lol I wanted to ask if anyone has suggestions on the minimum weekly starting dose? I don't know if weight/height/age make any difference to a starting dose or it's more of figuring out what individual effective minimum is by trial and error. For reference I am 5ft 2, about 145lbs and 45yo. Pretty healthy according to the latest blood work. Would love to get about 10ish lbs off, happy to take my time doing it. I was thinking of starting at .25mg per week, but unsure if it's too little?

Hot flashes can be seen not simply as a hormonal problem but as the visible sign of a deeper energy imbalance a flicker in the body’s power grid. Hormones aren’t useless they’re powerful messengers that often help restore balance when the system is struggling. But stopping at hormones is like patching a leak without checking the plumbing. We have to keep asking questions, digging deeper into why those hormones became imbalanced in the first place. Our goal isn’t to mask symptoms or apply temporary fixes; it’s to understand the root cause at the cellular and metabolic level so we can create true, lasting repair. The people who trust us with their health deserve that level of curiosity and commitment. We serve them best not by handing out patches, but by rebuilding the system underneath so it doesn’t keep breaking. At the foundation of that system is mitochondrial health. Mitochondria are the cell’s generators, producing energy in the form of ATP. When they falter, the hypothalamus the region that regulates temperature, sleep, and metabolism loses its steady rhythm. The result is the unpredictable heat surges we call hot flashes. The process unfolds in stages. In the earliest stage, subtle redox imbalances appear: the ratio of NAD⁺ to NADH drifts, and tiny sparks of superoxide begin to escape from the electron transport chain. You might imagine this as a dimming lightbulb the current still flows, but the wiring starts to hum. At this point, magnesium glycinate, niacinamide (vitamin B3), riboflavin (vitamin B2), and taurine help stabilize the system. Magnesium anchors ATP, keeping energy stored until it’s needed. Niacinamide and riboflavin recharge the batteries (NAD⁺ and FAD) that carry electrons through the mitochondrial turbines. Taurine acts as a shock absorber, buffering calcium shifts and protecting delicate membranes. Together they tighten the circuits so electrons can move smoothly again. Early signs that this is working are better sleep, fewer afternoon energy crashes, and steadier tolerance to stress or caffeine. On measurable levels, heart rate variability (HRV) improves, fasting glucose stabilizes, and body temperature becomes more consistent.

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👋 Hi, I’m Anthony Castore, SSRP Fellow, Strength Coach, and one of the few bridging elite performance with cutting-edge cellular medicine. With a background in peptide sciences, mitochondrial medicine, and advanced protocol design, I’ve helped high performers—from athletes to complex medical cases—reclaim their health, build unstoppable strength, and align biology with ambition. My work fuses rigorous science with real-world application—no fluff, no hype, just results. 🔑 Why This Community Exists This isn’t just my community—it’s yours. This is your training ground. Your lab. Your launchpad. Whether you’re here to optimize body composition, repair your gut, understand redox signaling, or finally crack the code on sustainable performance—this platform is built to empower you. The goal is simple:To help you become the star of your own story—and to equip you with the tools, knowledge, and frameworks to make clear, informed decisions rooted in science, lived experience, and real-time feedback. 📚 What You’ll Get Inside • Education that scales – From beginner-friendly breakdowns to advanced protocols rooted in systems biology and peptide pharmacology.• Discussion zones – Ask questions, share insights, and get direct input on supplementation, case studies, protocol design, and training periodization.• Office hours & mentorship access – Learn how the world’s top strength coaches and cellular medicine experts think, assess, and prescribe.• Ongoing content drops – Webinars, presentations, toolkits, and behind-the-scenes of real-world cases.• A true community – This isn’t a passive group. It’s an ecosystem of thinkers, doers, and seekers—supporting each other, growing together. 🚀 My Vision To build the most trusted education platform in performance medicine—one that empowers sovereign individuals to own their biology, train with precision, and age with intention. Not just to optimize, but to understand.Not just to do more, but to do better.And not just to follow protocols—but to design your own future with clarity and confidence.