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Castore: Built to Adapt

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3 contributions to Castore: Built to Adapt
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@Anthony Castore As far as the nutrition on certain days https://youtu.be/roB4KfR-_hg?si=ry06iHvv5ta2Y2q3
Training vs Rest Day Nutrition: How to Maximize AMPK/mTOR Balance and Mitochondrial Function
How should calorie intake be distributed between training and rest days to optimize AMPK vs mTOR signalling while supporting mitochondrial fission/fusion and redox balance? For example, in a weekly plan averaging 2400 kcal/day at maintenance, with 4 training days focused on myofibrillar hypertrophy (4–8 reps), 3 rest days including 40 min of fasted steady-state cardio, and ~10,000 steps daily. Would a large contrast between training and rest days (e.g., ~3000 kcal training / ~1600 kcal rest) be more effective than a moderate contrast (e.g., ~2700 / ~2000), assuming the same weekly average 2400? Should the calorie difference between training and rest days be set as a % above/below 2400 kcal, or should the contrast between the days fall within a specific range (e.g., 15–30%)? Does this range change depending on whether the goal is muscle gain or fat loss? Assuming ~1 g/lb protein on both days (open to adjustment if better for signalling or recovery). How much fat and carbs (grams or % of calories) should be consumed on training days for mTOR-driven hypertrophy (with most carbs consumed post-workout), and on rest days to support AMPK-driven adaptations?
October Q&A Saturday 25th 12 noon EST (link posted at the bottom of this announcement)
Join me for our October Live Q&A on Saturday, October 25 at 12:00 p.m. EST. We’ll dig into peptides, mitochondrial medicine, training and recovery design, and real-world protocol troubleshooting. Bring your questions (big or small), wins, sticking points, and labs or metrics you want decoded. Come ready to learn, take notes, and leave with clear next steps you can use the same day. To submit a question in advance, reply to this post with “Q&A” at the top and a concise summary of your question; live questions will be taken in order after pre-submissions. Save the date, invite a friend who’d benefit, and I’ll see you Saturday at noon. Here is the link to watch the replay of the Q&A thank you everone for joining and thank you for sending your questions in! https://us06web.zoom.us/rec/share/pcj7EkP9JA9hgj2SIcHeiFFgml4klErn_CRj33Nbb10OM0gmzh7itR_vKyHGXXwd.Cs3mioaqFw2jbYHe?startTime=1761407862000 Passcode: e4T2tR!l
1 like • Oct '25
Q&A I always played sports growing up, but I’ve had a skinny-fat physique for as long as I can remember. During a bulk, I reached around 195 lbs, but at least 30% body fat, and built somewhat of a base deadlifting 315 lbs 5×5, incline benching 185 lbs 5×5, and overhead pressing 140 lbs 5×5. After that, I did a long, aggressive cut (~6+ months) down to ~140 lbs on very low calories (~1,350–1,500/day) with lots of fasting. I lost a lot of fat but definitely muscle too. Even though I was beat and depleted after the cut, I felt much cleaner, lighter, and healthier—with inflammation reduced, face and body acne gone, etc. It’s kinda crazy saying I ate this low and was this aggressive for so long, but it showed me that I definitely have grit (learned a lot trying to force my body in AMPK)—I’m the type to do whatever it takes, always keeping the long term in mind and patient if the result will be better in the end. After that, I reversed calories very slowly up to ~2,200/day for about 3 months, gaining strength and feeling better and filling back up a bit. Currently, I’ve dropped calories back to ~1,350 for the past 3 weeks, and I’m maintaining all the strength I gained during the reverse, maybe I should’ve dropped slower. But my short-term goal is to get to 10% body fat so I can set up a proper lean bulk and never go above 15% again. I also think I may have a bit of muscle memory built up compared to how I look right now. 5’10 155 lbs 27 years old, around 19–20% body fat, training 4x/week with mostly myofibrillar/strength/CNS-focused training (8 reps at the most). I do 40 minutes of steady-state cardio on cardio days. I get 10,000 steps daily, and on days I don’t do cardio, I aim for at least 15,000 steps. I practice intermittent fasting so I can enjoy my meals more instead of spreading calories too thin. Year-round, my diet consists of whole foods: chicken breast, lean grass-fed ground beef, sockeye salmon, eggs, Greek yogurt, sweet potatoes, avocado, fruits, and vegetables. I set my maintenance at ~15× body weight (~2,325 calories) and adjust up from there. Protein 1g/lb body weight, 25% calories fat, and the rest carbs.
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Mason R
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1point to level up
@mason-r-9173
Let’s improve.

Active 3d ago
Joined Oct 23, 2025
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