Imagine your muscle system as a handmade Patek Philippe watch. Not a flashy accessory, but a mechanical masterpiece built from hundreds of micro-engineered components, each one tuned to transfer energy, rhythm, and precision. When a watch like this is young and perfectly calibrated, the movement runs smoothly, the second hand glides, the chronograph responds instantly, and every gear communicates with the next with almost zero friction. But as time passes, even the finest watch quietly drifts out of tune. Lubrication thickens. Gears lose polish. The escapement rhythm softens. Nothing breaks, but the internal conversation weakens. The watch still tells time, just not with the effortless elegance it once had. Aging muscle behaves the same way. Inside the cell, one of the signals that keeps everything responsive is PGE2, a messenger molecule that tells mitochondria how to renew themselves, activates stem cells for repair, and helps the neuromuscular system stay sharp. The enzyme that breaks PGE2 down is 15-PGDH. In youth, it functions normally. With age, it becomes overactive and wipes away PGE2 too quickly, the same way overcleaning a watch strips away its essential lubrication. The result is muscle tissue that feels slower, tighter, less coordinated, and less responsive to training not because the parts are missing, but because they’re no longer communicating clearly. A new compound being studied called MF-300 gently inhibits 15-PGDH, allowing PGE2 to remain active long enough to deliver its full message. Nothing is forced. Nothing is artificially overstimulated. Instead, the internal calibration is restored. Once PGE2 is back in the picture, it activates a receptor called EP4, which functions like the watch’s regulation lever guiding energy release, timing, and resilience. EP4 then activates PKA, a master switch inside the cell that initiates mitochondrial maintenance, improves calcium handling, stabilizes neuromuscular communication, and wakes up satellite cells for repair. Beginners can think of this like relubricating the watch’s movement. Experts will recognize it as the cascade of cAMP, CREB signaling, PGC-1α activation, and downstream transcriptional changes that rebuild energy systems and restore functional capacity.

I have a distorted sense of smell.I am going on Month 3 of a distortion and Month 6 since my loss of smell. The distortion makes everything smell and taste really bad so I have a hard time eating. I don't know what caused it but it is possible that it is a long Covid issue. I was not tested at the time I was ill as it seemed like a lingering mild sinus infection. I have lost 45lbs since July 21st but most of that has been since the distortion began August 18th. I am trying to find a path back to eating. I know I have a little more I can lose but at the pace I am going I will be at an unhealthy weight in about a month and a half. I would welcome any advice or a path forward to find a way to repair this. MRI was clean, scope clean. I am losing a battle and every trad doc I have seen just smile and tell me they have no answers. Sometimes I feel like I am not taken seriously. I have had my dna tested and now I am looking for inj vitamins but have no idea where to find them. Not looking for a cure...just a path forward.