What it is AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound that mimics cellular energy stress by activating AMPK, the body’s “fuel gauge.” What it’s known for Increases cellular energy efficiency Enhances glucose uptake and fat oxidation Supports endurance adaptations (often called an “exercise-mimetic”) Investigated for metabolic health and mitochondrial function How it works (simple) AICAR turns on AMPK → cells act like energy is low → body prioritizes burning fuel and improving energy pathways. Common research context Metabolic research Endurance and mitochondrial studies Insulin sensitivity models