What it is
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound that mimics cellular energy stress by activating AMPK, the body’s “fuel gauge.”
What it’s known for
Increases cellular energy efficiency
Enhances glucose uptake and fat oxidation
Supports endurance adaptations (often called an “exercise-mimetic”)
Investigated for metabolic health and mitochondrial function
How it works (simple)
AICAR turns on AMPK → cells act like energy is low → body prioritizes burning fuel and improving energy pathways.
Common research context
Metabolic research
Endurance and mitochondrial studies
Insulin sensitivity models