This space is built to be practical, educational, and useful. To make sure the content here actually serves you, I want to hear directly from you. Please comment below and tell me: What topics you want covered in more depth Specific peptides or categories you want broken down Whether you want more education, protocols, lifestyle application, or case studies

What it is ARA-290 (cibinetide) is a modified fragment of erythropoietin (EPO) designed to activate tissue-protective pathways without stimulating red blood cell production. What it’s known for Neuropathic pain support Nerve repair and protection Anti-inflammatory signaling Potential benefit in small-fiber neuropathy How it works It targets the innate repair receptor (IRR), helping calm inflammation and protect nerves instead of affecting hematocrit like EPO. Why people are interested Pain modulation without opioid pathways Neuroprotection without RBC elevation Being studied in diabetes-related nerve pain and inflammatory conditions Common research use (not medical advice) Often explored in short cycles rather than continuous use due to its signaling nature.

What it is AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound that mimics cellular energy stress by activating AMPK, the body’s “fuel gauge.” What it’s known for Increases cellular energy efficiency Enhances glucose uptake and fat oxidation Supports endurance adaptations (often called an “exercise-mimetic”) Investigated for metabolic health and mitochondrial function How it works (simple) AICAR turns on AMPK → cells act like energy is low → body prioritizes burning fuel and improving energy pathways. Common research context Metabolic research Endurance and mitochondrial studies Insulin sensitivity models

My stack is Reta, Mots-c, Klow, NAD+ and SS-31 Not every day, they all follow a schedule. My oura ring has told me since I started the 4 after Reta that my resting heart rate has been high. Is this normal? And does it settle back down? It’s sitting at 67 when I’m typically 55.

Interested in the GPL3 but not sure how to mix the backwater or how much to take. Hear to learn as much as I can 😊