What it is PE-22-28 is a short neuropeptide fragment derived from ACTH (adrenocorticotropic hormone). Unlike full ACTH, it does not stimulate cortisol release. What it’s known for Neuroprotection Cognitive support (learning, memory, focus) Anti-anxiety and stress resilience effects Potential mood stabilization How it works (simple) PE-22-28 acts on the brain’s melanocortin system, supporting neuronal signaling and resilience without activating the adrenal stress response. That’s the key distinction. Why people are interested Brain health without cortisol spikes Clean cognitive enhancement (not stimulant-based) Often discussed alongside Semax/Selank in nootropic research circles Typical research dosing (commonly discussed) Microgram range Often intranasal or subcutaneous Used in short cycles rather than continuously Important note This peptide is generally discussed in research-only contexts and is valued specifically because it separates mental effects from hormonal stress effects.

My stack is Reta, Mots-c, Klow, NAD+ and SS-31 Not every day, they all follow a schedule. My oura ring has told me since I started the 4 after Reta that my resting heart rate has been high. Is this normal? And does it settle back down? It’s sitting at 67 when I’m typically 55.

What it is AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound that mimics cellular energy stress by activating AMPK, the body’s “fuel gauge.” What it’s known for Increases cellular energy efficiency Enhances glucose uptake and fat oxidation Supports endurance adaptations (often called an “exercise-mimetic”) Investigated for metabolic health and mitochondrial function How it works (simple) AICAR turns on AMPK → cells act like energy is low → body prioritizes burning fuel and improving energy pathways. Common research context Metabolic research Endurance and mitochondrial studies Insulin sensitivity models

This program has been developed for individuals seeking to engage in strength training with limited equipment and without access to a gymnasium. 2 DAYS / WEEK – Full Body Principles (MAPS-style): Full-body each session Moderate volume Controlled tempo Focus on movement quality, not exhaustion Leave 1–2 reps in reserve on most sets DAY 1 – STRENGTH FOCUS 1. Tempo Bodyweight Squat 4 sets x 8–10 3 sec down / 1 sec pause / up 2. Push-Ups (elevated if needed) 4 sets x 8–12 Controlled, full range 3. Backpack Row 4 sets x 10–12 Pause 1 sec at top 4. Hip Thrust (couch or bench) 3 sets x 12–15 Squeeze glutes hard 5. Front Plank 3 sets x 30–60 sec Rest: 60–90 sec between sets DAY 2 – CONTROL + ATHLETIC FOCUS 1. Split Squat (rear foot elevated optional) 3–4 sets x 8–10 / leg Slow and controlled 2. Pike Push-Ups (or incline shoulder press) 4 sets x 6–10 3. Single-Leg Romanian Deadlift (bodyweight or backpack) 3 sets x 10–12 / leg 4. Inverted Row (table, rings, or bands) 3 sets x 8–12 5. Dead Bug or Hollow Hold 3 sets x 8–12 reps or 30 sec hold Rest: 45–75 sec

I just want to know what the best peptide is for each thing I want Skin: I'm guessing ghkcu but I want to know if any help with over reactive blood vessels in the face Tan: I already have light freckles so im not sure about mt2 Anxiety/nervous system: not sure Brain function/increasing intelligence: semax maybe I’m not sure about others