Hi all, This was something I only recently became aware of so though i should share it. Key Findings from Research :https://pmc.ncbi.nlm.nih.gov/articles/PMC3262853/ Animal Study Evidence: A 2011 study in mice found that pretreatment with fenbendazole (at doses equivalent to 8–12 mg/kg/day for 7 days) significantly worsened acetaminophen-induced liver damage. Specifically:Acetaminophen alone caused centrilobular hepatic necrosis and elevated liver enzymes (ALT/AST) within 12 hours.When combined with fenbendazole, the damage was more extensive, with greater necrosis, higher enzyme levels, and 63% mortality within 24 hours.Fenbendazole alone did not cause liver issues.The mechanism appears to involve prolonged depletion of glutathione (GSH), a key antioxidant that detoxifies acetaminophen's toxic metabolite (NAPQI). Fenbendazole delayed GSH recovery without altering acetaminophen's metabolism or major cytochrome P450 enzymes (except a minor suppression of CYP1A2).This interaction was investigated because fenbendazole is commonly used in lab rodents, and it highlights a potential drug-drug effect in hepatotoxicity models. Human Relevance: There are no published clinical trials or case reports confirming this interaction in humans. Fenbendazole is not FDA-approved for human use (it's a veterinary dewormer), so data is limited to off-label contexts like experimental cancer protocols. Both drugs are metabolized in the liver via the cytochrome P450 system, which could theoretically lead to similar risks, such as altered drug clearance or compounded stress on liver function. Sites promoting fenbendazole use (e.g., for alternative therapies) note this as a speculative concern and recommend monitoring liver enzymes (ALT/AST) if combining them, along with liver-supportive supplements like milk thistle.

Awesome informational paper on the uses of DMSO. https://www.midwesterndoctor.com/p/dmso-mixtures-transform-natural-medicine?r=1aazmf&triedRedirect=true

Presently, the subscapular pain due to the cancer in my spine and ribs has been particularly bad, with sharp, stabbing pain. The pain in my left hip has moderated greatly. then moved to my right hip, and has moderated a lot the past week, so the left subscapilar pain is still the focal point of pain. I got back on Celebrex this week, since I can now use Tylenol, in moderation, which is a Cox 2 inhibitor, one type of pain that Tylenol is good for dealing with. It was able to help me reduce my need for morphine, but after 3 days of going cold turkey to get off morphine, I have found the kind of pain morphine is good for removing, has still been needed as the pain level reaches 9 and 10 at times. Since my histotripsy I received in Oregon, 10/23/25, about 1/3 of my cancer was ablated from the 2 larges masses, which allowed me to get back on Tylenol products when needed. I have been acutely aware that one cannot live with level 9 and 10 level pain, no matter how hard one tries. I used ice packs, gabapentin, and alternated with hot backs, and did contrast therapy, and whirlpool, and am waiting to receive a pulsed ultrasound from China, and don't know when it will arrive, as it's being held up with tariffs, though taxes, and duties were prepaid. When my friend Dr. Howard returns from Spain, he told me to come to his house and we will try various modalities, as he doesn't want to see me on pain meds anymore than I have to. The cryoablation is scheduled for the 21st of this month, which should remove 90% of my pain generation, and pain meds that go with it. How is everyone else dealing with their cancer pain?

According to Prof. Angus Dalgleish, by using LDN, a patient may be able to lower the dose of a cancer drug, such as chemo. A lower dose chemo is obv. a lower dose toxicity. He explains. https://m.youtube.com/watch?v=cbATdSa7pTM

Hey guys, just wondering if anyone has had problems with liver dysfunction during their treatment. Dad has been on fenbendazole (222mg, 6 days a week) and ivermectin (1mg/kg) for six weeks with no issues. Started pembrolizumab/carboplatin 10 days ago and today had a blood test showing liver dysfunction with ALT around 1000, up from 40 2 weeks prior. The doctors are thinking it's autoimmune from the pembro, and treating as such. Anyone had liver function go off to that degree with fenben? Thanks