Vagus Nerve Stimulation: Breakthrough For Rheumatoid Arthritis Relief

Great news in Vagus Nerve world for you guys:

RESET-RA trial: Vagus nerve stimulation reduces rheumatoid arthritis severity.

A double-blind study of 242 patients.

Active group received cervical vagus nerve stimulation via implanted device for 12 weeks.

Device activates cholinergic anti-inflammatory pathway (CAP).

Acetylcholine release suppresses cytokine production (TNF-α, IL-1β, IL-6).

DAS28-CRP score reduced by 1.9 points in active group vs. 0.7 in sham (p<0.0001).

CRP, ESR, TNF-α also significantly declined.

52% achieved ACR50 in active group vs. 22% in sham.

Comparable mild adverse events observed.

Vagus nerve stimulation targets inflammation, validating CAP for rheumatoid arthritis treatment.

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