Revolutionizing Nerve Stimulation With The First Flexible Ultrasound Cuff

Jerry Li, an electrical engineering concentrator, developed a flexible cuff as his senior capstone project. The cuff uses ultrasound rather than electrical currents to stimulate the vagus nerve with precision.

The approach is presented as having the potential to be less invasive and more targeted than prior methods. Applications noted include future treatment of depression, epilepsy, or support for neuroprosthetic control.

Li stated that to his knowledge no one has used microfabricated ultrasound transducers for peripheral nerve stimulation before.

Microfabrication work began in May 2025 and continued over the summer. Electronics design was the focus during the academic year.

The microfabrication process itself was described as the most challenging element, characterized as a long and detailed procedure even with expert guidance.

The project drew on multiple disciplines including neuroscience, phased array theory, wireless charging, and mechanical prototyping. Li noted that the interdisciplinary scope helped build his confidence as an engineer.

The work was conducted under the Harvard John A. Paulson School of Engineering and Applied Sciences.

https://www.facebook.com/hseas/posts/for-his-senior-capstone-project-electrical-engineering-concentrator-jerry-li-dev/1342732331285198/

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Revolutionizing Nerve Stimulation With The First Flexible Ultrasound Cuff