Ive been blown away by the healing potential of peptides. I want you to heal to so here is some info to consider. These are not fda approved so most doctors will not recommend them.
Peptides are small proteins that are encoded in our DNA. They help the body function properly. Peptides are strings of amino acids in a specific sequence, like letters of a word. There are many peptides out there and some are still quite unproven so use caution. The healing ones I have been using have the longest history of safety and efficacy and I feel confident recommending them. I do not recommend any others.
I’ve been using the Wolverine stack which is BPC157 mixed with TB500. This healing peptide mix has miraculously helped me heal decades old spinal injuries as well as new bumps and breaks like a recent rib injury. I take it via subcutaneous self injection via insulin syringe. Tiny needle doesn’t hurt.
BPC-157 (Body Protection Compound-157) is a 15-amino-acid peptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) first identified by Dr. Predrag Sikiric in 1991 from gastric tissue extracts. More than 180 peer-reviewed studies have explored its interactions with fibroblasts, endothelial cells, and inflammatory mediators.
In laboratory models, BPC-157 has been investigated for cell-protective and anti-inflammatory actions that appear to influence several signaling systems:
Activation of VEGFR2 → Akt → eNOS pathways associated with endothelial repair and microvascular stability.
Modulation of growth hormone receptor (GHR) → JAK2 signaling in fibroblast cultures, studied in connection with collagen formation and wound-model tissue remodeling.
Regulation of nitric-oxide (NO) balance and up-regulation of antioxidant enzymes such as heme oxygenase-1 (HO-1), often cited as part of its anti-oxidative and cytoprotective profile.
In preclinical injury and inflammation models, BPC-157 has been observed to reduce pro-inflammatory cytokine expression and support tissue regeneration processes via enhanced fibroblast migration and angiogenesis.
TB-500 is a synthetic peptide identical in amino-acid sequence to thymosin beta-4 (Tβ4), an actin-binding protein widely studied for its roles in cell migration, cytoskeletal regulation, and inflammation control. Tβ4 has been described in over 900 scientific papers; TB-500 itself has appeared in 11 peer-reviewed publications as a research analog.
TB-500 is frequently used in research exploring cellular motility, inflammation modulation, and repair biology:
Influences actin polymerization, aiding in cell structure organization and migration during tissue-model experiments.
Interacts with integrins and VEGF signaling, pathways known to participate in angiogenesis and matrix remodeling.
Demonstrates down-regulation of inflammatory mediators and up-regulation of repair-related genes in non-clinical wound-healing models.
For the last couple months I have also been trying out Ipamorelin mixed with CJC1295 with no DAC. This is a growth hormone secretagogue. It helps the body produce more GH. This one is far less studied and carries more risk so I cannot recommend it for everyone. I have seen faster muscle development and recovery from my workouts. I am cautiously using at a lower dose than recommended.
Ipamorelin acts as a selective growth hormone–releasing peptide (GHRP). It binds to the ghrelin receptor (GHS-R1a) to promote GH release in pituitary cultures.
CJC-1295 (no DAC) is a growth hormone–releasing hormone (GHRH) analog derived from the first 29 amino acids of native GHRH.
Physiological Context of GH / IGF-1 Signaling (For Research Reference)
In scientific literature, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are recognized for their wide-ranging roles in cellular metabolism and tissue maintenance:
Skeletal and connective tissue:
Promotes collagen synthesis and matrix turnover in bone and cartilage models.
Muscle physiology:
Supports protein synthesis and myocyte differentiation in culture systems.
Adipose and metabolic research:
Regulates lipolytic and glucose-handling pathways under endocrine control.
Skin and wound-model systems:
Stimulates fibroblast proliferation and angiogenic signaling in vitro.
Neural and cognitive studies:
Influences neurotrophic factor expression and synaptic plasticity pathways.
Hepatic and systemic regulation:
Coordinates IGF-1 synthesis in hepatocytes, modulating systemic feedback to the pituitary.
Soon I will try out NAD+ (for longevity), Selank (anti-anxiety for my wife), and Semax (a nootropic or cognitive enhancer).