Question on the Randle Cycle · Carnivore Coach International

Question on the Randle Cycle

Hi everyone,

In Module 7 - The Randle Cycle of the CCI course, I think there's a little piece of information missing (or that I missed):

In both glucose and fat "modes", citrate concentration increases in the cytoplasm.

In fat mode, citrate inhibits glucose absorption in the cell.
In glucose mode, citrate is converted into Acetyl-CoA, only then into Malonyl-CoA. Malonyl-CoA inhibits fat oxidation.

What is not clear to me is : why in fat mode, the citrate inhibits glucose while following the same chemical chain reaction that leads to Malonyl-CoA and therefore should ALSO result in fat oxidation inhibition (that obviously does not occur).

My understanding is that the only difference when looking at citrate > Acetyl-CoA > Malonyl-CoA chain reaction is the concentration levels of ACL and ACC enzymes are lower in the cytoplasm. Is it correct ?

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Question on the Randle Cycle