1. Nausea and GI tract Discomfort - is due to a slowing of the gastric emptying and changes in appetite. (Try smaller meals and avoid fatty meals. Antacids may help.) 2. Constipation or Diarrhea - happen stop changes in gut mobility. (Try Miralax and stay hydrated if constipated. Loperamide is recommended for diarrhea control in research environments.) 3. Electrolyte Imbalance - could happen due to reduced caloric intake and rapid weight loss. (Take electrolytes and stay hydrated.) 4. Increased Heart Rate - this one is an often alarming and surprising side effect of GLP3 caused by increased metabolic activity. Electrolyte imbalance can make it worse. (Stay hydrated, reduce caffeine and stimulants, if condition worsens see your DR.) 5. Skin Sensitivity (Allodynia) - this side effect happens due to sensitization of the nervous system. Users report feeling pain in the skin or sensitivity to touch or contact. (Usually resumes on its own.) • 6. Excess Appetite Suppression - sometimes appetite suppression is too strong and this is not good. Low caloric intake could lead to muscle loss and vitamin/nutrient deficiency. (Lowering the dose helps, eating protein dense food and having a comprehensive diet to support