❇️ If you've been following the metabolic peptide space lately, you've probably seen 5-Amino-1MQ pop up more and more. It's not a traditional peptide — it's a small molecule — but it's earned its place in research circles for one very compelling reason: it targets an enzyme called NNMT, and the downstream effects are seriously interesting. ❇️So What Is NNMT, and Why Does It Matter? NNMT stands for Nicotinamide N-Methyltransferase — an enzyme that methylates nicotinamide (a form of vitamin B3), effectively pulling methyl groups away from the metabolic pool and reducing NAD+ availability. When NNMT is overactive (which it tends to be in obese and insulin-resistant individuals), it acts like a metabolic brake. You get lower NAD+, slower mitochondrial function, and a harder time burning fat. 👉🏼 5-Amino-1MQ blocks NNMT. That's its whole job — and by doing so, it lets NAD+ levels rise naturally. ❇️ What the Research Shows 🔸 Preclinical studies have highlighted some notable effects: ➡ Fat loss without caloric restriction: In mouse models, NNMT inhibition led to significant reductions in body fat, even without changes to diet. The mechanism appears tied to increased energy expenditure at the cellular level. ➡ NAD+ elevation: Higher NAD+ means more fuel for sirtuins (especially SIRT1) and improved mitochondrial efficiency — both linked to longevity and metabolic health. ➡ Muscle preservation: Unlike aggressive caloric deficits that chew through lean mass, NNMT inhibition appears to preferentially target adipose tissue. ➡ Improved insulin sensitivity: Early data suggests better glucose handling, which is particularly relevant for metabolic syndrome research. ❇️How It's Different From NAD+ Precursors: You might be thinking: "Why not just take NMN or NR?" Fair question. Those work by directly adding NAD+ precursors to the system. 5-Amino-1MQ works differently — it removes the enzyme that's draining NAD+ in the first place. Think of it less like adding water to a leaky bucket and more like patching the hole. Some researchers believe this makes it especially relevant for metabolically compromised models where NNMT is chronically upregulated.

❇️ Introduction Most peptides get attention for physical performance — muscle, fat loss, recovery. Selank flips the script. Developed by the Institute of Molecular Genetics in Russia, this heptapeptide analog of tuftsin has been generating serious interest for its dual ability to reduce anxiety and enhance cognitive function — without the sedation or dependency risks associated with traditional anxiolytics. If you're exploring peptides beyond the gym, Selank deserves a closer look. 🧬 The Science Selank (sequence: TKPRPGP) is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin. Its primary mechanism involves modulating the expression of BDNF (brain-derived neurotrophic factor) and stabilizing enkephalin — endogenous opioid peptides that regulate mood and stress responses. Crucially, Selank doesn't simply suppress anxiety by sedating the CNS; it appears to recalibrate the GABAergic system in a more balanced way than benzodiazepines. Beyond mood, Selank also influences serotonin metabolism and has shown the ability to modulate expression of genes related to immune function, making it one of the few research compounds that bridges neurology and immunology. It has a very short half-life (minutes in plasma), which is why intranasal delivery is the most studied administration route — it allows rapid CNS access via the olfactory pathway. 👉🏼 Animal studies have consistently shown Selank to improve learning, memory consolidation, and attention. These cognitive benefits appear to be distinct from its anxiolytic effects, suggesting multiple independent mechanisms at play. 🔸 Research Highlights • In Russian clinical trials, Selank showed anxiolytic efficacy comparable to medazepam (a benzodiazepine), with significantly fewer side effects and no reported dependency. • A 2008 study found Selank significantly increased BDNF expression in rat hippocampus — a key marker for neuroplasticity and memory formation. • Research published in the Bulletin of Experimental Biology and Medicine found Selank stabilized enkephalin degradation, prolonging natural opioid mood regulation without exogenous opioid activity.

I know this is all over the place and feel free to dump links - I'm looking for YOUR stack and protocol and I will adjust accordingly. I just received a mini-shipment of excess from a colleague to have my go, before I buy retail or reseller. 2x CJC+IPA 5mg/5mg (research tells me 200mcg a night?) 2xMOTS-C 10mg (2mg daily in the morning, 5x a week?) 2x Reta 10mg (I'm coming off Tirzepatide @ 7.5mg. It's been working without going up in dose, hunger is at bay, weight loss is flat now, but feel great. I just want to try Reta for a couple months. Thought 2mg a week and titrate up?) Background: I am 3 weeks off TRT (reasons) and hope to get back on it soon. The effects are definitely noticeable though, brain fog, loss of energy, just feel like I can give 100% in my workouts, but I'm realistically at 60%.