🧠 Tesofensine — The Nuero Fat Burner + Appetite Suppressant❓
Daily Deep Dive: Tesofensine was originally developed for Alzheimer’s and Parkinson’s, but it ended up showing powerful fat loss effects — around 10%+ body weight reduction in 6 months in clinical trials. Here’s what’s going on under the hood 👇 ⚙️ Mechanisms of Action Tesofensine is a triple monoamine reuptake inhibitor, meaning it blocks the reuptake (or recycling) of dopamine, norepinephrine, and serotonin in the brain. That does a few key things: 🧩 1. Increased Dopamine → Motivation & Drive - Dopamine elevation boosts energy, focus, and reward signaling. - This is one reason users report more motivation to train and a general “feel-good” effect. - However, too much dopamine activity over time can lead to tolerance or burnout, so cycling or taking breaks helps. 🔥 2. Increased Norepinephrine → Fat Mobilization - Norepinephrine is your “fight or flight” hormone — it raises metabolism, heart rate, and thermogenesis. - By keeping norepinephrine elevated longer, tesofensine promotes greater lipolysis (fat breakdown) and energy expenditure even at rest. 🍽️ 3. Increased Serotonin → Appetite Suppression - Serotonin plays a major role in satiety and mood regulation. - Higher serotonin = stronger appetite control, fewer cravings, and greater satisfaction from smaller meals. - This is one of the primary reasons tesofensine works so well for weight loss — it directly reduces food intake at the brain level. ⚡ Net Effect - ↓ Appetite (stronger than phentermine) - ↑ Energy expenditure & fat oxidation - ↑ Mood, focus, and motivation - ↓ Cravings and emotional eating 🧬 Additional Notes - Tesofensine does not act like a stimulant (no direct amphetamine structure), but the neurochemical profile is similar to a mix of bupropion + phentermine + serotonin modulators. - Because it acts centrally, dosing too high can cause jitteriness, sleep disruption, or elevated blood pressure. - Common cycle length: 8–12 weeks, followed by a break to prevent receptor desensitization and dopamine depletion.