Everyone's focused on the incredible fat loss results with retatrutide, but there's a critical side effect that's flying under the radar: significantly elevated resting heart rate. This isn't your typical GLP-1 nausea that goes away in a few days. This is a cardiovascular effect that demands respect and careful attention. What's Actually Happening in Your Research Models? Retatrutide is a triple agonist - GIP/GLP-1/glucagon. That third component, glucagon, is what sets it apart from tirzepatide and semaglutide, and it's also what's driving this side effect. Here's the mechanism: Glucagon receptor activation: - Dramatically increases metabolic rate and energy expenditure (great for fat loss) - Activates the sympathetic nervous system (your "fight or flight" response) - Stimulates thermogenesis (heat production) - Increases cardiac output to support elevated metabolism The result? Your heart starts beating faster to keep up with the increased metabolic demand. This isn't a bug - it's a feature of how the compound works. But it comes with real implications. The Clinical Trial Data In Eli Lilly's Phase 2 trials: - Average RHR increases of 5-10 bpm were common - Some subjects saw increases of 15+ bpm - The effect was dose-dependent (higher doses = higher RHR) - The elevation persisted throughout treatment duration - It didn't just "go away" after a few weeks like GI side effects To put this in perspective: if your baseline RHR is 65 bpm and you jump to 80 bpm, that's your heart beating an extra 21,600 times per day. Over a year? That's nearly 8 million extra heartbeats. Why This Matters More Than You Think An elevated RHR isn't just uncomfortable - it has real physiological implications: Cardiovascular strain: - Increased workload on the heart muscle - Higher oxygen demand - Potential for increased blood pressure - Greater stress on the cardiovascular system long-term Quality of life impacts: - Feeling "wired" or anxious - Poor sleep quality - Reduced exercise capacity - Palpitations or awareness of heartbeat

Hi, Sorry i know i’ve been posting wuite abit here but i promise i’m slowing down after this haha. Anyways my RS is off retatrutide and finally on Tirzepetide(lowest effective dose) because reta was messing with the body’s sleep(6hr or less), Heart Rate issues 80s+ while resting on bed and occasional constipation. I loved the metabolic burn result at rest but not my RS felt on it. My RS entered a muscle building recomp phase so calories/carb and activity in general are up and id like the RS to build muscle and lose fat. I am wondering if introducing a “metabolic boost”/energy peptide to help with fat gain from the surplus would be worth it. I’m talking about: MOTSC, 5 Amino 1mq, SLU PP, tesofensine, AOD, Tesa/ipa, cjc/ipa, Ipa, semoraline etc…(fyi my RS is 25yo in Rat years👀) I especially looked into tesofensine which sounds very enticing because my RS struggles with mental focus when working after morning workouts but it seems like it would be worse than retatrutide even at low daily dose lol. Anyways sorry for the long post, and i’d appriciate any feedback from the community.

That first picture? It scares me to death to post this. I was scared, sad, and disappointed in myself. But I think it’s important. This was over the course of 5 years. 250 → 170 at my leanest this summer. And trust me, there were plenty of bumps in the road on this journey. I’m not posting this for praise or attention. I’m posting this because if you’re in the thick of it right now — feeling stuck, falling off track, wondering if it’s even worth it — I want you to know it is. There was no magic moment where it all clicked. There were setbacks, binge cycles, weeks where I felt like I was going backwards, and moments where I genuinely didn’t know if I’d ever get here. But I kept showing up. Not perfectly. Just consistently enough. 80 pounds didn’t come off overnight. It came off one decision at a time, over and over again, for years. If you’re on this path — whether you’re just getting started or you’re deep in the grind — keep going. The version of you on the other side is worth every single hard day. Let’s go. 💪

After long reserach, i have decided to provide my RS with Tesofensine(lowest effective doee possibe) and tirz(lowest effective dose). Kind of a ghetto reta if you will. My RS was on reta but it took TOO much of a stress on their body. We saw the result but sleep, HR, HRV was destroyed. Still waiting to get it out of the system before starting this new combo Has anyone used this combo on their lab rat? And yes i did see derek’s breakdown of the compound, but would still like to hear other people’s experiend while researching these.

My RS has been on reta for awhile now and the heart rate and Sleep just are not coming down despite trying alot a bunch of things. I recently came across Tesfensine and it seem very appealing but i am seeing some bad conflicting information on it. Can you guys talk about you RS’s experience with it? Thank you