RESEARCH DISCLAIMER: Everything here is about research subjects (RS) and lab protocols only. These peptides are NOT for human use - research purposes exclusively. Alright, so here's what's happening with my RS over the holidays: Taking a 2-week break from everything except reta. And no, I haven't lost my mind. This might actually be the smartest research decision I've made in months. We All Do This... Your protocol is running smooth. RS responding great. Recovery looking good. Then your brain goes: "But what else could I add? What's next?" More peptides. More stacks. More everything. But here's what I've been thinking - sometimes one step back = two steps forward. Whether it's for observational reasons or just protocol management, taking breaks will ALWAYS show you something when you reintroduce compounds to your RS. What Actually Happens (The Science Part) ---- GH Peptides (CJC, Ipa, MK-677) Your research model's receptors downregulate with constant stimulation. Those amazing initial results? They fade because the biological system adapts. Take 2-4 weeks off → receptors normalize → reintroduce → BAM, those first doses hit different again. Healing Peptides (BPC-157, TB-500) Constant signaling = saturation point in the research model. Additional dosing stops translating to additional healing in your data. Breaks let inflammation markers normalize and healing cascades complete naturally. Reintroduction produces way more pronounced responses. Skin Peptides (GHK-Cu,) Fibroblasts get exhausted from constant stimulation in research. 4-6 week breaks = everything resets. Especially important with copper peptides to avoid accumulation. Metabolic Peptides (GLP-1s) Real talk - receptor desensitization happens. You might notice changes in satiety markers at the same dose over time. (I'm keeping reta because that's my metabolic foundation, but rotating or full breaks have major value too) The Part Nobody Talks About Beyond receptors and mechanisms... there's the protocol management side.

After trying DSIP with zero results, I found something that actually worked. Not a sleep "drug." Not another melatonin supplement. A peptide that works through an entirely different mechanism—one that's been studied for 35+ years (mostly in Russia) with some pretty wild implications beyond just sleep. The best part? The sleep improvements feel natural. No grogginess. No dependency. Just easier wind-down and better quality rest. What makes it different: It doesn't just knock you out like a sedative. It works by regulating your pineal gland and supporting your body's natural melatonin production. But that's just the beginning of what it does... The deeper mechanism involves something called telomeres (your cellular "aging clock") and an enzyme most of your cells don't produce anymore. I broke down the full science, mechanisms, research, and my lab rat's 15-day protocol in my latest deep dive. Read the full breakdown here: https://open.substack.com/pub/derekpruski/p/understanding-epithalon-the-longevity?r=4jq1x8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Including: ✅ How it actually works (explained simply) ✅ Why telomeres matter for sleep AND longevity ✅ The research behind it ✅ Real-world 15-day protocol results ✅ Dosing and cycling protocols Worth a read if you're struggling with sleep or just curious about the intersection of peptides, longevity science, and cellular health. Drop a comment if you've tried this one—curious to hear your experiences. 👇

Tomorrow kicks off the biggest event of the year at Peptira, and I want you to have the full schedule so you can strategically time your orders (or orders if you want multiple entries 😉). 🎁 HOW IT WORKS SITEWIDE DISCOUNTS (STACKABLE): - ✅ 15% OFF automatically applied December 13–24 - ✅ PLUS Code DEREK for an extra 10% OFF - 💥 Total savings: 25% OFF when you stack! MEGA GRAND PRIZE DRAWING: Every single order placed December 13–24 automatically enters you for a chance to win your choice of: - 🖨️ Bambu Lab P1S Combo 3D Printer ($899 value) - 💰 $500 Peptira Store Credit (Grand prize winner drawn from ALL 12 days of orders) 📅 DAILY GIVEAWAYS - 2 WINNERS EACH DAY Here's your strategic guide to the 12 Days: 🎁 Day 1 - December 13 Peptira Hoodie 🥤 Day 2 - December 14 Peptira Tumbler 💵 Day 3 - December 15 $50 Store Credit 💼 Day 4 - December 16 Peptira Branded Case by Biocase Innovations 🎁 Day 5 - December 17 Hoodie/Tumbler Bundle 💰 Day 6 - December 18 $100 Store Credit 💼 Day 7 - December 19 Peptira Branded 100-Vial Case by Hambino 🧪 Day 8 - December 20 Half-Kit of Winner's Choice 🎁 Day 9 - December 21 Hoodie/Tumbler Bundle 💸 Day 10 - December 22 $200 Store Credit 🎊 Day 11 - December 23 MEGA Merch Pack 🖨️ Day 12 - December 24 (GRAND FINALE) Bambu Lab P1S Combo 3D Printer (Plus this winner is drawn from ALL 12 days of orders!) All of these will be added to peptideprice.store/sales 🎯 BONUS PERKS ✈️ FREE 2nd Day Air Shipping on all orders $250+ 🎟️ Multiple entries? Place multiple orders throughout the 12 days! 📦 Any size order counts - even small orders get you entered! 🛒 SHOP NOW 👉 https://peptira.com/?ref=Derek Use Code: DEREK at checkout for maximum savings! Let the holiday research begin. 🔬 FOR RESEARCH USE ONLY

Alright, so Lilly dropped their TRIUMPH-4 Phase 3 data yesterday for retatrutide. 28.7% weight loss. 71 pounds average. At 68 weeks. If you've been paying attention to triple agonists, this shouldn't be surprising. The Phase 2 data already showed us where this was headed. But now we have the Phase 3 confirmation. Here's what happened: 445 people with obesity and knee osteoarthritis. Split into three groups - 9mg retatrutide, 12mg retatrutide, and placebo. The 12mg group lost an average of 71.2 pounds. That's 28.7% of their starting weight. Compare that to tirzepatide's ~21% in Phase 3. That's 8 percentage points higher. The glucagon agonism makes the difference - you're not just suppressing appetite, you're ramping up energy expenditure and fat oxidation. Why triple agonists hit different: Retatrutide is GIP + GLP-1 + Glucagon. You already know GLP-1 from semaglutide. You know the dual combo from tirzepatide. The glucagon piece is what pushes this into a different category. - GLP-1 = appetite control - GIP = metabolic optimization - Glucagon = fat-burning accelerator You're hitting all three mechanisms simultaneously. The inflammation piece is wild: This trial was designed for knee osteoarthritis, not just weight loss. The pain results were massive: - 76% reduction in pain scores - 74% improvement in physical function - 12% of people completely pain-free by week 68 But here's what's interesting - this wasn't just about losing weight and reducing load on the joints. Retatrutide crushed inflammatory markers across the board. hsCRP dropped significantly. Triglycerides down. Blood pressure down 14 mmHg. Each component has anti-inflammatory effects. GLP-1 reduces pro-inflammatory cytokines. GIP has protective effects on bone and cartilage. Glucagon ramps up fat burning, and less adipose tissue means less inflammatory signaling. You're not just taking pressure off the knee - you're turning down systemic inflammation that's driving the pain in the first place.

Hey everyone - there's been some stuff I've been dying to fix. The whole reason PeptidePrice exists is because I wanted to build THE all-in-one tool that makes it stupid easy for every researcher to make informed decisions. You're about to see some big changes coming: 1. Stackable Discounts (finally fixing this) I've seen the confusion with Valor's sale and Peptira's pricing before - their sites auto-markdown prices (like $100 → $80), then your coupon code applies on top (80 → $72). Right now that's not super clear on my site. Don't worry, I have a fix for this and it's coming soon... 2. No More "Ghost" Sales I'm actively staying on top of retailers now. Not launching ANY sales or products on the site until I personally verify they're live and functional. Too many times I've had owners say "hey this is live" → I check and it's out of stock or coupons don't work. Not a good look for me, so even if sales are delayed a bit, I want the best experience for you all. 3. Price Tracking is LIVE (retailers, I see you 👀) The backend price tracking tool is running. If I catch a price hike right before these sales, I'm calling it out and advertising based on what prices were just days ago. So far since Black Friday, it's been solid. PSA to all retailers: 30% off isn't 30% off when you hike prices up 20% first. Not acceptable. Run your business how you want, but I'm gonna keep it real. 4. Shipping Updates Shipping costs and policies have been changing like crazy. I haven't been keeping it 100% up to date - that's changing NOW. Adding this to my daily updates with some advanced features to make it more visible on the site. 5. Content Strategy Shift Content will still come out, but I'm trying to be more impactful with every post. This might mean less overall volume, but I want to break down the full picture so you can make informed decisions as researchers. Quality over quantity. 6. 2026... 👀 I'll keep the bonus features quiet for now, but you're not ready for what's coming. PeptidePrice will continue to level up. We don't stop.