I saw this paper had arrived in my email this morning. I think it’s a good survey of what HBOT is thought to help with respect to standard of care cancer treatments.

So lots has transpired since we first thought Boone had osteosarcoma at his skull. Actually it turned out to be nasal carcinoma that migrated to the skull. Biopsy determined it to be an undifferentiated carcinoma (fairly aggressive growth). What this meant was radiation therapy as SOC and limited expected success with chemo options afterwards. We chose to do SRT (3 days at 10 GY fractions). It’s been 6 weeks since we finished the radiation therapy. Since it wasn’t osteosarcoma, Boone could not be considered for Yale University’s immunotherapy clinical trial (polyclonal canine antibody equivalent of the human monoclonal Cetuximab). The antibodies target over expressed HER2 or EGFR proteins. For Boone this means his carcinoma will need to over express EGFR (~ 70% chance per some published papers I’ve reviewed). However, Yale approved Boone to receive the vaccine under compassionate access and he gets the first shot this week, then the second shot at 21 days. The vet draws blood samples at baseline, 21 days, and 45 days. These are sent back to Yale to the contribute to the immune response data for nasal carcinoma cancers. Hopefully we can add to the improvements of future immunotherapy methods. — Ok, so that’s the conventional approach we’ve committed to following. Meanwhile, on the alternative front, since early January I began a treatment of Fenbendazole (10mg/lb) 6 days per week with milk thistle liver support, and added immunity boosting mushroom supplements. I transitioned Boone to a ketogenic diet (~ 70%fat/28% protein/2% net carbs daily). Most recently I have added modified citrus pectin (MCP). This is due to a paper I found that indicated MCP may help increase the effectiveness of Cetuximab antibodies by interfering with free Galectin-3 molecules (makes it more difficult for tumor cells to mass together or metastasize). So the alternative approach is to attack the cancer cells by Fenbendazole’s disruptive mechanisms, starve the cancer cells of glucose, and try hard to help the immune system bolstered by the vaccine antibodies to go to war with the cancer.

I never imagined I would be writing this. My mum passed away, and I don’t yet have the words to describe the emptiness she’s left behind. She wasn’t just my mother — she was my best friend, my anchor, my reason for fighting, and the heart behind everything we built here. This community was created for her. She carried more than most people ever see. She lived with bipolar disorder. She carried childhood trauma. She endured a painful divorce, the loss of both her parents, a cancer diagnosis, the death of Pepper — our family boxer — and the loss of Albert, our family’s closest friend. All of this happened within the last seven years. And yet — she kept going. She walked at least 10,000 steps a day. She swam three times a week. She went to church every Sunday. She worked tirelessly on the house. She quit smoking after her diagnosis. She tried carnivore. She cut out sugar. And most importantly: She kept our family together. She fought. She cared. She loved. Even when depression weighed heavily on her will to live, she chose to fight — not because it was easy, but because she loved us. She fought for us when her mind told her to give up. That is courage. We were hopeful. So hopeful. She had just started the Astron Health protocol — only one week in — and we believed we had time. Previous scans had been relatively reassuring, showing stable, very slow-growing, localised disease in the peritoneum and a coeliac lymph node, with no organ spread. Her CRP was 4 — within the normal range. Then everything changed — fast. She developed sudden, severe gastrointestinal pain, vomiting, and diarrhoea. We rushed to the hospital. A CT scan showed ischemic colitis. A mouth swab also confirmed COVID. She was put on palliative care, given fluids and heparin. Her circulation improved. Lactate came down. Symptoms improved. Objectively, things were getting better. But the narrative never changed. Despite improving vitals, improving markers, and improving symptoms, they continued to insist on bowel necrosis — even when the evidence did not clearly support it. At the same time, her CRP (an inflammation marker) rose rapidly from 4 (normal) just weeks earlier, to 14 on admission, to 150 the following day, and eventually to 455 at its peak. She developed rising oxygen requirements, hypoxia, and what appeared to be a clear systemic inflammatory storm — yet COVID pneumonitis was repeatedly dismissed.

Every time o read about the cancer vaccine i filled with joy that the day is near to make world cancer free and to get back to the normal! But this scares me too what if it get delayed ! What if it doesn’t workout! What’s your thought about the news lingering around these vaccines?

So for the past 15 months I’ve been studying alternatives for a lifelong friend with Stage 4 colon cancer. Last week we confirmed our 12 yr malti-poo has bone cancer on his skull above his eye. Well all this prior study on FenBen and metabolic therapy has already been in use for dogs as pet owners adapted the Joe Tippens protocol, and added nutritional supplements for immune support (eg turkey tail mushrooms, etc), and metabolic strategies. So off I go on a journey to transition Boone to ketogenic diet, and FenBen (atleast in the short term). My goal right now is to get him stable with the pain from the tumor and confirm if/how much metastasis has occurred (ie lungs, lymph nodes most likely). Then we decide next steps. Chemo is not favored because track record for remission is poor, and I don’t want to put him through that. A vaccine based immunotherapy clinical trial exists that’s of strong interest but we have to get any metastatic spread under control to be eligible. ———— So that’s the backstory of this past week. This morning I’m reading a research paper about Ketone supplementation. I didn’t even know such product commercially existed. I understand so many of you trying metabolic therapy struggle to get GKI into the target range. I haven’t fully comprehended the conclusions, but it does seem the researchers found benefit for ketone supplementation in the in-vivo mice study. This paper was co-authored by Thomas Seyfried in 2014. Does anyone know if he later determined the results of ketone supplementation was not effective? https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.28809