Osteosarcoma in our beloved maltese-poodle Boone

So for the past 15 months I’ve been studying alternatives for a lifelong friend with Stage 4 colon cancer. Last week we confirmed our 12 yr malti-poo has bone cancer on his skull above his eye. Well all this prior study on FenBen and metabolic therapy has already been in use for dogs as pet owners adapted the Joe Tippens protocol, and added nutritional supplements for immune support (eg turkey tail mushrooms, etc), and metabolic strategies. So off I go on a journey to transition Boone to ketogenic diet, and FenBen (atleast in the short term). My goal right now is to get him stable with the pain from the tumor and confirm if/how much metastasis has occurred (ie lungs, lymph nodes most likely). Then we decide next steps. Chemo is not favored because track record for remission is poor, and I don’t want to put him through that. A vaccine based immunotherapy clinical trial exists that’s of strong interest but we have to get any metastatic spread under control to be eligible.

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So that’s the backstory of this past week. This morning I’m reading a research paper about Ketone supplementation. I didn’t even know such product commercially existed. I understand so many of you trying metabolic therapy struggle to get GKI into the target range. I haven’t fully comprehended the conclusions, but it does seem the researchers found benefit for ketone supplementation in the in-vivo mice study. This paper was co-authored by Thomas Seyfried in 2014. Does anyone know if he later determined the results of ketone supplementation was not effective?

https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.28809

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