One of the most common questions I see is: “When should I up my dose?” But here’s what most people miss: The caloric deficit is what’s driving your weight loss, not the dose number. GLP-1s work by reducing hunger and food noise, making it easier to maintain a deficit. So if you’re already not hungry and have no food noise at your current dose, increasing won’t magically speed up your results - it’ll just increase your risk of side effects. Signs you might actually need to increase: ✅ Appetite suppression is wearing off noticeably ✅ Food noise is coming back strong ✅ You’re getting genuinely hungry between meals again ✅ You’re struggling to maintain your deficit ✅ You’ve given it 4+ weeks and the effects have clearly diminished Before you increase, optimize EVERYTHING else first: 🎯 Are you actually tracking your intake? (Most people eat more than they think) 🎯 Are you hitting your protein target? (Keeps you fuller longer) 🎯 Are you getting enough sleep? (Affects hunger hormones massively) 🎯 Are you managing stress? (Cortisol drives cravings) 🎯 Are you lifting weights? (Preserves muscle, boosts metabolism) 🎯 Are you staying hydrated? (Often mistaken for hunger) The truth bomb: If you’re not hungry and have no food noise but aren’t losing weight, the issue isn’t your dose - it’s that you’re eating at maintenance. More medication won’t fix that. Tightening up your nutrition will. When you should definitely WAIT: 🛑 Still experiencing side effects from current dose 🛑 Having any GI issues 🛑 Haven’t given your current dose a full 4 weeks 🛑 Haven’t dialed in your nutrition and lifestyle factors yet Remember: These medications are tools to make the deficit easier, not magic. The dose that controls your hunger IS the right dose for you right now. What’s been your experience? 👇

Do you have a consolidated document that shows best time of day for administration of various peptides? Looking for cheat sheet showing optimal morning vs evening, fasting or not, which not to give with others at same time, etc.

The Golden Rule: Never Double Up If you miss a day of your peptide protocol, resist the urge to "make up for it" by taking extra doses. Just start back up the next day like nothing happened. Here's why this approach is not just safe—it's optimal. The Biological Mechanisms: Why Doubling Doses Backfires 1. Receptor Saturation and Downregulation Peptides work by binding to specific receptors on your cells. These receptors operate on a "Goldilocks principle"—they need just the right amount of stimulation. When you double your dose to compensate: - You oversaturate available receptors, but the "extra" peptide doesn't translate to extra benefits - Your body interprets this flood as a threat and begins downregulating (reducing) receptor expression - This creates tachyphylaxis—reduced responsiveness to the peptide over time - You're essentially making your protocol LESS effective long-term by trying to be more aggressive short-term Real-world analogy: It's like shouting at someone who heard you the first time. They don't understand you better—they just start tuning you out. 2. Half-Life Doesn't Stack Like You Think Most therapeutic peptides have carefully calculated half-lives: - Growth hormone secretagogues (like Ipamorelin, CJC-1295): 2-4 hour half-lives - BPC-157: approximately 4-6 hours - TB-500: longer acting, 7-10 days Your protocol is designed around these pharmacokinetics. When you double dose: - You don't "catch up" on the time-dependent tissue remodeling effects - You create unnaturally high peak concentrations your tissues aren't adapted to handle - You risk side effects without proportional benefits The tissue healing, collagen synthesis, or metabolic effects happen over time with consistent signaling—not from concentration spikes. 3. Hormonal Cascade Disruption Many peptides trigger hormonal cascades (growth hormone, IGF-1, etc.). These systems have negative feedback loops: - Overshooting triggers your body to pump the brakes harder - You can suppress your natural production more than intended - The resulting hormone fluctuation can cause mood instability, sleep disruption, or metabolic confusion

I’m a 50 year old menopause woman. Yes, I’m on HRT. Started with Reta to help shed 30 pounds, no results. If anything, just a tender stomach from the shots Thinking of switching to Triz. Looking to see if anyone else has gone the same route with results?

This is just a quick reminder—if anyone is trying to claim some expertise by saying they are a Peptide Specialist, Certified Peptide Educator, or anything of the sort, it's complete BS. Even the advisors at Telehealth Companies that are "Wellness Specialists" have little to no experience with these peptides personally. Don't blindly trust anyone. Peptides are a new and evolving field with very few clinical studies. I saw a video today of someone claiming you should only purchase with them because they are a Peptide Specialist ensuring their sources are "the highest quality". Do your research and always check COAs. As someone who's gotten a complete view of the research space, it's kind of sad how little education there is out there and how many people try to cling to titles. Even some company owners don't understand how peptides work/are made, which is mind blowing. I will never claim to know everything about peptides—I only have a small knowledgebase. I think I have a unique view of the research space, and my goal is to give you the background so you can ask questions and verify things yourself. The sites on peptideprice.store will continue to maintain a solid quality standard with testing, customer service, and operate with transparency. If they start to slip and aren't putting customers first, they will be removed. That's my promise to you guys—let's keep this thing growing together! The more questions the better so everyone can learn from each other 🫶