Hey guys just wanted to give a little update on my Dad's lung cancer journey and see if anyone had any thoughts on his progress. Ideas and inputs greatly appreciated! - Diagnosed with stage 3c lung adenocarcinoma July 2025 - Started keto diet, ivermectin 1mg/kg daily and fenbendazole 400mg a few weeks later - Felt strong, good appetite able to walk 2-3km per day, weight 75kg - August 2025 - seen by oncology team in Melbourne and offered 'palliative' chemo and immunotherapy, not eligible for radiation or surgery due to mets to mediastinum and supraclavicular lymph nodes - Had one dose of carboplatin and keytruda September 2025 - 10 days later admitted to hospital with severe liver dysfunction (enzymes around 1000), presumed autoimmune hepatitis due to keytruda (liver pre treatment was fine) - Commenced high dose steroids and mycophenolate with gradual recovery of liver - Ceased fenbendazole as every time we reintroduced it the liver function worsened. No further immunotherapy of chemo - Continued keto diet (gki 2-5 mostly), ivermectin and gradually added in some other supplements - metformin, berberine, melatonin, quercetin, Artemissinin, ECGC, mebendazole (now 100mg daily), TUDCA, silymarin, vit d with k, Resveratrol - Gradual weight loss since September 2025, down to 60kg - January 2026 finally got off the steroids - January 2026 developed diarrhoea - diagnosed with microscopic colitis presumed due to keytruda from september, ?previously suppressed due to steroids. Required hospital admission for high dose steroids and fluids - No improvement in diarrhoea until infusion of infliximab, now settled and weaning steroids again - Feb 2026 also started IV vitamin C 2ish times per week, can only do 30mg due to problems with the salt load - Ongoing weight loss 56kg, very fatigued and weak, struggling with appetite, out of keeping with improvement in colitis The good news in all of this is that the cancer has been relatively stable on every scan since metabolic therapy and chemo/immuno. Much to the surprise of his oncologist considering he only had one dose of chemo and immuno.

To help everyone connect more easily with others on a similar journey, please comment below with: 1. Your Cancer Type (e.g., Cervical Adenocarcinoma, Triple-Negative Breast Cancer, Glioblastoma, etc.) 2. (Optional) Stage/Grade (e.g., Stage 3, Grade 2). Example: “My mum: Cervical Adenocarcinoma, Stage 4.” This way, members can find and connect with others who truly understand the specifics of their situation. Feel free to browse the comments and reach out to those you relate to!

Dostarlimab (Jemperli), a PD-1-blocking immunotherapy, has shown unprecedented results in treating locally advanced mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) rectal cancer, with 100% clinical complete response (cCR) rates in multiple studies. Phase II Study (NCT04165772): A landmark trial led by Memorial Sloan Kettering Cancer Center (MSK) found that all 12 patients treated with neoadjuvant dostarlimab achieved a clinical complete response, with no evidence of tumor after 6 months of treatment, and no need for chemotherapy, radiation, or surgery. Updated 2024 Data (ASCO): An expanded analysis of 42 patients confirmed a 100% sustained clinical complete response with a median follow-up of 26.3 months. No patients experienced disease recurrence or required additional therapy. Key Outcomes: No evidence of disease confirmed via MRI, endoscopy, digital rectal exam, and PET scans. No grade 3 or higher adverse events reported. Durable responses observed for over 2 years, with no local or distant recurrences. Regulatory Status: The US FDA granted Breakthrough Therapy Designation to dostarlimab for this indication in December 2024, based on the remarkable results. Ongoing Research: The AZUR-1 trial (NCT05723562) is a global, phase II registrational study evaluating dostarlimab monotherapy as a first-line treatment for untreated dMMR/MSI-H locally advanced rectal cancer, with the goal of confirming these findings in a larger cohort. This treatment offers a paradigm shift by potentially eliminating the need for life-altering surgery, chemoradiation, and their associated long-term side effects, especially for young patients and those in childbearing years.

I never imagined I would be writing this. My mum passed away, and I don’t yet have the words to describe the emptiness she’s left behind. She wasn’t just my mother — she was my best friend, my anchor, my reason for fighting, and the heart behind everything we built here. This community was created for her. She carried more than most people ever see. She lived with bipolar disorder. She carried childhood trauma. She endured a painful divorce, the loss of both her parents, a cancer diagnosis, the death of Pepper — our family boxer — and the loss of Albert, our family’s closest friend. All of this happened within the last seven years. And yet — she kept going. She walked at least 10,000 steps a day. She swam three times a week. She went to church every Sunday. She worked tirelessly on the house. She quit smoking after her diagnosis. She tried carnivore. She cut out sugar. And most importantly: She kept our family together. She fought. She cared. She loved. Even when depression weighed heavily on her will to live, she chose to fight — not because it was easy, but because she loved us. She fought for us when her mind told her to give up. That is courage. We were hopeful. So hopeful. She had just started the Astron Health protocol — only one week in — and we believed we had time. Previous scans had been relatively reassuring, showing stable, very slow-growing, localised disease in the peritoneum and a coeliac lymph node, with no organ spread. Her CRP was 4 — within the normal range. Then everything changed — fast. She developed sudden, severe gastrointestinal pain, vomiting, and diarrhoea. We rushed to the hospital. A CT scan showed ischemic colitis. A mouth swab also confirmed COVID. She was put on palliative care, given fluids and heparin. Her circulation improved. Lactate came down. Symptoms improved. Objectively, things were getting better. But the narrative never changed. Despite improving vitals, improving markers, and improving symptoms, they continued to insist on bowel necrosis — even when the evidence did not clearly support it. At the same time, her CRP (an inflammation marker) rose rapidly from 4 (normal) just weeks earlier, to 14 on admission, to 150 the following day, and eventually to 455 at its peak. She developed rising oxygen requirements, hypoxia, and what appeared to be a clear systemic inflammatory storm — yet COVID pneumonitis was repeatedly dismissed.

His YouTube title: Ketosis (Fasting/Ketogenic Diet) accelerates Cancer Growth - New Study. If not, he must be living under a rock if he doesn't know about Prof Seyfried, Dr. Dominic D'Agostino, and many reputable researchers who understand the science behind the ketogenic diet. In a time when C patients are fighting for their lives and searching for hope in ketogenic diet and other metabolic therapies, does this YouTuber muddy the waters even more? 😔 Patients deserve clarity, not confusion. BUT... the good thing is that in the comment section, some folks in the know have pushed back on his narrative. As a follower of Prof Seyfried’s metabolic principle, I gave this YouTuber a thumbs down. What is your take? https://www.youtube.com/watch?v=joa0zk8sb1E&t=161s