@Diane Hinkle If you're still getting food noise, try pinning your dose once every 5 or 6 days instead of doing it once a week or split dosing your weekly dose 3.5 days apart ( I did this and it's helping with that appetite suppression - I get hungry on days 5-7). . Cagri - what is your dosage on that and are you pinning 3 days apart from Tirz? If you've been on it for four weeks, go up. You're likely not at a therapeutic dose on Cagri. You can also try decreasing your Tirz dose down from where you're at now, increase your Cagri, hold there for four weeks, then Titrate back up on Tirz. Sometimes this gives a mini reset. Supplements aren't gonna cut appetite suppression. Dial in on your protein intake (1g of protein per pound of body goal weight per day), staying well hydrated with electrolytes (80-120oz daily) and getting enough fiber in (15-25g - it'll help you feel fuller longer)