Python is an interpreted language and it has its uses in certain contexts, however it's really not good for performance-intensive large-scale projects like a video game, for various reasons. Languages like C# and Java are better than python performance-wise but they're still not ideal since the garbage collector bogs down the performance by quite a tremendous amount. C++ is better since it's not garbage collected, and therefore the programmer has more control over the program (and is therefore able to optimize for games better), but C is preferred since it's not as featureful and is far easier to tell what's actually going on at a low-level than something that's more obfuscated such as C++ and it's tendency towards an object-oriented model of programming. You can still program in C++ cautiously without falling into some of the pitfalls of the language (like the way Casey Muratori and others program), but C often forces you into a more straightforward way of programming that helps you better understand the inner workings of the program and things like data structures and how they work for example.

Transformation matrix math is definitely the thing I would like to the most focus on.