Clinical trial alert: Non-invasive ultrasonic auricular vagus nerve stimulation (uaVNS) is under investigation. Launched December 16, 2025, the trial employs low-intensity focused ultrasound (LIFU) via a wearable ear device. LIFU targets the auricular branch of the vagus nerve. Acoustic pressure waves mechanically activate voltage-gated ion channels. This promotes afferent signaling to brainstem nuclei, enhancing parasympathetic outflow. Inflammation is modulated via the cholinergic anti-inflammatory pathway. Compared to transcutaneous electrical VNS (taVNS), uaVNS offers superior penetration and spatial precision. No skin irritation. The double-blind, randomized, sham-controlled study includes 80 adults with major depressive disorder. Protocol: 30-min daily sessions for 12 weeks. Primary endpoint: MADRS reduction. Secondary: HRV, cytokine levels, fMRI. Preclinical rodent models show uaVNS yields a 25% greater HRV increase. Locus coeruleus norepinephrine modulation is 40% more robust than taVNS. https://clinicaltrials.gov/study/NCT07283913

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The main difference between the two is power but does stronger automatically mean better? Did the stronger 2000 lead to faster or better results? For those who have both, what made one model better for you than the other?