The Best Peptides for Preserving Fertility on TRT (substack post here - https://open.substack.com/pub/prml/p/your-balls-on-testosterone-the-sciencebacked?r=eiljo&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true) Testosterone Replacement Therapy (TRT) does wonders for energy, mood, and muscle — but there’s a catch: **it shuts down the brain‑testicle conversation that keeps sperm production alive**. When exogenous testosterone enters the bloodstream, the brain stops producing gonadotropin‑releasing hormone (GnRH). That drop silences luteinizing hormone (LH) and follicle‑stimulating hormone (FSH), causing testicular shrinkage, low sperm counts, and infertility.[1][2] The solution isn’t to abandon TRT — it’s to *biohack the communication loop* with the right peptide support. hCG: The Clinically Proven Workhorse: Human chorionic gonadotropin (hCG) has long been the go‑to fertility safeguard for TRT users. It **acts as an LH mimic**, directly telling the Leydig cells in your testes to keep producing testosterone and sperm. - Men who stack TRT with low‑dose hCG (250–500 IU, 2–3x per week) typically **maintain testicular volume, ejaculate consistency, and fertility window** — even while fully suppressed by external T.[3][2][1] For men planning to father children, no peptide has more clinical mileage than hCG. It’s been used in fertility clinics for decades and is still considered the **gold standard for preserving sperm health on TRT**. Kisspeptin‑10: The Upstream Innovator: Enter **Kisspeptin‑10**, the rising neuropeptide challenger. - Unlike hCG, which works *downstream*, kisspeptin activates the *top* of the reproductive axis — stimulating the hypothalamus to release natural GnRH, which triggers FSH and LH pulses that restore proper rhythm to the entire system.[4][5][6]

(More in depth post: https://prml.substack.com/p/peptides-cjc-1295-hcg-natural-testosterone) Most guys hit a wall in their 30s or 40s — low energy, slower recovery, softer look. Before jumping on TRT, try this: CJC-1295 + HCG — a peptide combo that reactivates your own hormone system. What It Does CJC-1295 → boosts natural growth hormone HCG → boosts natural testosterone Together they: - Burn fat while protecting lean muscle - Improve deep sleep and recovery - Reignite libido, drive, and mood - Keep your system natural (no shutdown) Why It Works - CJC-1295 increases GH + IGF-1 → faster recovery, better sleep, fat loss - HCG mimics LH → your testes produce more testosterone - The combo = more energy, better workouts, and leaner composition Typical Educational Dosing - CJC-1295 (no DAC): 100–200 mcg morning + before bed - CJC-1295 (with DAC): 2 mg once weekly - HCG: 250–500 IU 2–3× per week (SubQ injections. For educational purposes only — always consult a qualified provider.) What You’ll Notice ✅ Leaner midsection ✅ Deeper sleep and recovery ✅ Higher libido and confidence ✅ Stronger lifts and faster repair Bottom Line You’re not replacing hormones — you’re reactivating them. More GH. More T. More life. 💬 COMMENT “Stack” if you want a free custom protocol based on your goals.

Link to Substack post (formatted nicer): https://prml.substack.com/p/how-i-healed-a-full-labrum-tear-without 💥 The Moment Everything Snapped I still remember the pop. My shoulder gave out mid-set — and the MRI confirmed what I already knew: a torn labrum. The doc said the same thing everyone hears: “You’ll probably need surgery if you want full function again.” But here’s the twist — I didn’t go under the knife. Six months later, my orthopedic follow-up showed a fully healed labrum. No surgery. No cortisone. Just strategic recovery, smart loading, and two powerful peptides: BPC-157 and TB-500. ⚙️ What I Used: The Science-Backed Peptide Stack 1. BPC-157 (Body Protection Compound-157) Originally discovered in gastric juice Shown in animal studies to accelerate tendon-to-bone healing, angiogenesis, and fibroblast migration Stimulates VEGF, FAK, and GH receptor pathways linked to cellular repair May improve micro-circulation and nitric oxide signaling, helping avascular tissues (like the labrum) regenerate 2. TB-500 (Thymosin Beta-4 Fragment) Synthetic version of a naturally occurring peptide involved in actin regulation and cell migration Known to promote angiogenesis, stem cell mobilization, and anti-inflammatory effects Used in early human wound-healing trials for skin and corneal injuries 🔬 Why It Worked (According to Research) Most labral tears don’t heal easily because the tissue has poor blood flow. That’s where this peptide combo shines. BPC-157 works by increasing angiogenesis — the formation of new blood vessels — while boosting fibroblast activity and growth-factor signaling. It essentially tells your body, “Hey, send resources here. Let’s rebuild.” TB-500, on the other hand, enhances cell migration and actin remodeling, helping the right cells actually move into the injured area to start the repair process. It’s also anti-inflammatory and supports microcirculation around the injury.

You finally got lean on GLP-1s — and now your libido’s gone missing. Here’s what’s going on: 👉 GLP-1s (Ozempic, Wegovy, Retatrutide, Mounjaro) calm hunger and your brain’s reward system. That means you’re less interested in food — and sometimes, less interested in sex. 👉 Appetite suppression + rapid fat loss can throw off hormones short-term and bump up SHBG, which binds up your free testosterone. 👉 The result? Lower drive, weaker erections, and a general “meh” feeling even when you look your best. The natural fix: 💊 Tongkat Ali — frees up bioavailable testosterone and improves mood 💊 Tribulus Terrestris — boosts nitric oxide, blood flow, and libido Stack example: • Tongkat Ali – 200 mg/day • Tribulus – 750 – 1500 mg/day Together they help restore that primal spark GLP-1s can flatten — so you can stay lean and keep your edge. The in depth post with links to studies and deep dive can be found on my substack here: https://prml.substack.com/p/hot-body-no-boner-the-glp-1-side

Most men think the only way to raise testosterone is to go on TRT. Wrong. You don’t always need an outside source of testosterone — you can reactivate your own factory if your system’s still intact. That’s where peptides come in. These compounds can signal your body to start producing more of its own testosterone instead of replacing it. Here’s what actually works — backed by physiology and real data. ⚡ 1. hCG (Human Chorionic Gonadotropin) Think of hCG as synthetic LH. It binds straight to your testicular Leydig cells and tells them to crank out more testosterone. - Mechanism: Mimics LH → direct testicular T production - Use: Great for maintaining testicular function or fertility (even while on TRT) - Dose (typical): 250–500 IU 2–3×/week - Downside: It can raise estrogen slightly, so you need to monitor levels. Verdict: The most clinically proven way to raise natural T through the LH pathway. 🧠 2. Kisspeptin-10 (or Kisspeptin-54) This one’s exciting — it works upstream at the brain level. Kisspeptin tells your hypothalamus to release GnRH, which triggers your pituitary to release LH and FSH, which then drive testosterone and sperm production. - Mechanism: Activates the entire HPG axis (GnRH → LH/FSH → T) - Research: Human studies show rapid LH + testosterone spikes within an hour of dosing. - Dose (research use): 100–200 mcg 2–3×/week subQ - Status: Research-only for now, but it’s the most natural “reset button” for your HPTA. Verdict: The true natural testosterone peptide — the one to watch. 🔁 3. Gonadorelin (GnRH analog) Gonadorelin is the synthetic version of the same hormone Kisspeptin triggers. It’s powerful if used correctly — which means pulsed dosing, not random injections. - Mechanism: Pulses LH + FSH release from the pituitary. - Catch: If you use it continuously or in big doses, it desensitizes receptors. - Best use: In clinical settings to restart the HPTA after shutdown or in true GnRH deficiency. Verdict: Great in theory, complicated in practice — it needs a pump to mimic natural pulses.