11h (edited) • General discussion
PCOS and GLPs
This isn’t just “lose weight” → ovaries work better.”
GLP -1s show benefits beyond weight loss for those with PCOS. They also improved reproductive functionality. 🔍
⚠️ the 2023 international evidence-based PCOS guidelines now recommend GLP-1s for PCOS in research settings. Research is promising, but we need more long-term data and this decision shouldn’t be taken lightly - as they come with side effects. ⚠️
How do they work?
It’s not just from a knock on effect from the metabolic effects which we already know about, it’s literally signaling your ovarian cells to function more normally.
‼️86% ovulated on GLP-1 + metformin (vs 29% metformin alone)
🔄 62% had more regular periods.
🤰🏻 IVF pregnancy per transfer: 86% (typical PCOS rate 30%)
📉 Testosterone dropped
How GLP-s work for PCOS at multiple levels:
🧠 Brain: modulates hypothalamic pathways to optimize hormone release
🥚 Ovaries: GLP-1 receptors exist IN your ovaries. It works directly on folic development, reduces cystic follicles, supports normal ovulation
📌 Insulin: improves insulin sensitivity. This is crucial because high insulin drives your ovaries to overproduce testosterone - fix the insulin, help reduce the androgens.
🔥 Inflammation: GLP-1s reduce inflammation markers which improves both metabolic health AND helps your ovaries function normally.
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PCOS and GLPs
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