9h • General discussion
GLP: NOT “WHICH IS BEST.” WHICH IS RIGHT.
❇️ Everyone wants to know: Is Reta better?
But “Better” depends on what you’re measuring and what matters to you.
Here’s an honest comparison of al three GLPs
Sem - GLP-1
Triz - GLP-1 + GIP
Reta - GLP -1, GIP and Glucagon
Weight Loss: The Numbers
Average weight loss in major trials:
Medication - Duration - Weight Loss
Sema 2.4mg - 68 weeks - 14.9%
Tirz - 75 weeks - 20.8%
Reta - 68 weeks - 28.7%
👉🏼 Important: These are different trials, different populations. Not head-to-head.
Tolerability: Who Stops
Discontinuation rates due to side effects:
Medication - Drop Out Rate
Sema 5-7%
Tirz 7-10%
Reta 12-18%
👉🏼 Higher efficacy seems to come with higher dropout rates. This is a real trade-off to consider.
⚠️ Side Effects Profiles
All three share:
- Nausea, vomiting, diarrhea, constipation
- Decreased appetite
- Generally dose related
👉🏼 Reta has additional side effects:
- Dyesthesia (abnormal skin sensations): up to 21%
- Potentially more intense GI effects at high doses
❇️ What’s NOT Being Compared:
Critical Gaps:
- No head to head trial exists between GLPs
- Long-term data for Reta limited to 68 weeks
- Cardiovascular outcomes not yet available for Reta
- Real world effectiveness may differ from trial results
These are controlled trial comparisons - not guarantees.
Different Medications, Different Situations
1️⃣ Sema may be right if:
- You want the most long-term safety data
- Lower intensity side effects preferred
- Cost/access is primary concern
2️⃣ Tirz may be right if:
- You want more efficacy than Sema
- Good balance of results and tolerability
3️⃣ mReta might be right if:
- Maximum efficacy is a priority
- Willing to accept potentially more side effects
The right GLP choice depends on YOUR goals, timeline, and how your body responds.More options is good for everyone!
0
0 comments
GLP: NOT “WHICH IS BEST.” WHICH IS RIGHT.
powered by
skool.com/peptide-resource-center-3431
We are here for you because we've been there. Get support, education, resources and more!!!
Suggested communities
Powered by