8h • General discussion
Peptide of the Day: PE-22-28
What it is
PE-22-28 is a short neuropeptide fragment derived from ACTH (adrenocorticotropic hormone). Unlike full ACTH, it does not stimulate cortisol release.
What it’s known for
Neuroprotection
Cognitive support (learning, memory, focus)
Anti-anxiety and stress resilience effects
Potential mood stabilization
How it works (simple)
PE-22-28 acts on the brain’s melanocortin system, supporting neuronal signaling and resilience without activating the adrenal stress response. That’s the key distinction.
Why people are interested
Brain health without cortisol spikes
Clean cognitive enhancement (not stimulant-based)
Often discussed alongside Semax/Selank in nootropic research circles
Typical research dosing (commonly discussed)
Microgram range
Often intranasal or subcutaneous
Used in short cycles rather than continuously
Important note
This peptide is generally discussed in research-only contexts and is valued specifically because it separates mental effects from hormonal stress effects.
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Peptide of the Day: PE-22-28
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