2d • General discussion
PEPTIDE OF THE DAY: ARA-290
What it is
ARA-290 (cibinetide) is a modified fragment of erythropoietin (EPO) designed to activate tissue-protective pathways without stimulating red blood cell production.
What it’s known for
Neuropathic pain support
Nerve repair and protection
Anti-inflammatory signaling
Potential benefit in small-fiber neuropathy
How it works
It targets the innate repair receptor (IRR), helping calm inflammation and protect nerves instead of affecting hematocrit like EPO.
Why people are interested
Pain modulation without opioid pathways
Neuroprotection without RBC elevation
Being studied in diabetes-related nerve pain and inflammatory conditions
Common research use (not medical advice)
Often explored in short cycles rather than continuous use due to its signaling nature.
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PEPTIDE OF THE DAY: ARA-290
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