New Paid Tier in the Methylation Hub - Paid tier opens tomorrow: recorded sessions plus direct messaging for broad recommendations, not treatment - One-on-one sessions possibly in the future - Priced at 29 USD a month to start, for the first 50 people; annual is 290 USD, saving 2 months' worth - Annual Members get the MTHFR clinician guide (currently 59 USD) free, plus its upcoming upgraded version - Fertility Unasked Questions answered, and Archive foundations content stay free; implementation content moves to paid Over Methylation - Symptoms within days of starting: anxiety, feeling wired, insomnia, palpitations, headaches, irritability - Excess methyl groups build SAME; byproduct SAR inhibits COMT, so dopamine accumulates, worse with slow COMT genetics - Labs: normal homocysteine, high B12 and high folate - Management: pause methyl donors, test potassium to rule out hypokalemia, switch to hydroxy B12, restart methyl folate low and slow Methyl Trapping - Methionine synthase lacks enough B12, so 5-MTHF gets stuck, and homocysteine rises - Labs: normal or high serum folate, high homocysteine, low or low normal active B12, elevated methylmalonic acid - - RBC folate preferred over serum folate - Management: give B12 first, restart methyl folate after a couple of weeks, retest homocysteine Key Takeaways - The difference is B12: one needs B12, the other needs fewer methyl donors - Treat labs combined with genetics, not the MTHFR genotype alone (e.g. homozygous 677, up to 70% slower) - Prefer hydroxy or hydroxy plus adenosylcobalamin over methyl B12 where possible - You can send questions for the next live via DMs or post in the methylation group Q&A section

Saturday recording is here. Today I discussed a case in the order of the Archive, going through the different modules. Case study: 38-year-old woman, wired, anxious, disrupted sleep after starting methylfolate She is Compound Heterozygous: one copy of C677T and one copy of A1298C Your questions are welcome!

You got an MTHFR result. Then what? For most people, that moment goes one of two ways. Your doctor glanced at it and said, "It's not clinically significant." Or you fell down a rabbit hole of contradictory websites, Facebook groups, and supplement protocols that left you more confused than when you started. Neither of those should happen. That's exactly why this community exists. I'm Jean-Marc — integrative physician, 25 years in clinical practice, and probably the only doctor you'll meet who gets genuinely excited about methylation genetics. I created The Methylation Hub because the gap between what the science tells us and what patients actually receive is one of the most unnecessary failures in modern medicine. You deserve better than a shrug or a supplement shopping list. This is what you'll find here Clinical depth without the jargon. Evidence-based answers to the questions your GP didn't have time for. A community of people who understand what it means to feel like your biology has been working against you — and are figuring it out together. Every Thursday at 8 pm UK time, I host a live Q&A. Bring your labs, your questions, your confusion. Nothing is too basic, and nothing is too complex. Sessions are recorded if you can't attend live. The Classroom will have structured modules on methylation fundamentals, supplement protocols, and fertility, with more added regularly. One thing before you do anything else Go to the Introductions category and answer this single question: What is your MTHFR variant, and what is the one question you most want answered? That's it. One question. I read every introduction personally and respond to each one. You're not joining a database. You're joining a conversation that could genuinely change how you understand your own health. Welcome. Jean-Marc Sobczyk, MD - The Methylation Doctor